Physical Activity and Mild Cognitive Impairment

Dear Colleagues,

With the absolute and relative numbers of elderly persons increasing in societies around the world, age-related loss of cognitive function poses a major challenge for humanity, particularly when the deficits extend beyond those expected in normal aging. This state in which cognitive deficits are not yet significant enough to interfere with the activities of daily living is termed mild cognitive impairment (MCI). The major problem with MCI is that many of those affected by it will develop dementia later in life, such as Alzheimer's; hence, their daily living will be impaired up until the loss of self-dependence. Therefore, measures to prevent, or at least postpone, the progression from MCI to dementia are urgently needed. However, as of today, there are no approved medications for the treatment of MCI. This deficiency has drawn attention to non-pharmaceutical prevention and intervention strategies. Among those, physical activity is one of the most promising approaches, which has positive effects not only on cognitive functions, but also on cardiovascular and other functions, such as balance. However, what exercise is best for an individual, how much is needed and what are the mechanisms behind the observed effects? This Special Issue aims to shed more light onto these questions and, therefore, may provide important information on how brain function can be stabilized in individuals at high risk for dementia, namely, those suffering from MCI.

Prof. Dr. Notger Müller
Guest Editor

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