Special Issue "Recent Breakthroughs in Technetium Chemistry"

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 31 August 2019.

Special Issue Editor

Guest Editor
Prof. Dr. Adriano Duatti

Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via L. Borsari, 46, 44121 Ferrara, Italy
Website | E-Mail
Interests: inorganic chemistry; radiopharmaceutical chemistry; radiometals; molecular imaging; radionuclide therapy

Special Issue Information

Dear Colleagues,

The first ever discovered artificial element, technetium, has played a pivotal role in promoting the growth and remarkable success of nuclear diagnostic imaging in the past decades. Actually, a group of radiopharmaceuticals labelled with the gamma-emitting radioisotope technetium-99m are still employed as standard imaging agents in the routine clinical practice of different medical specialties, ranging from cardiology to oncology, for the diagnosis of a number of diseases. Despite current overwhelming emphasis on positron emission tomography (PET), it is interesting to note that one of the first-line approaches for the assessment of coronary artery disease (CAD) is still based on the use of technetium-99m myocardial imaging agents, the impact of PET tracers in this field being still limited. It is easy to recognize that the most important reason for this long-lasting success of technetium-99m radiopharmaceuticals resides in the richness of the chemistry of this transition element. Only the existence of a multitude of stable chemical motifs and structural arrangements for technetium complexes has allowed investigation of the biological and diagnostic properties of a large spectrum of coordination compounds and eventually the discovery of useful imaging agents. Thus, the study of the inorganic chemistry of technetium has been at the root of the success of this class of radiopharmaceuticals.

Today, we are at the verge of a new era for technetium-99m radiopharmaceuticals after many years of obscurity. New outstanding technological developments are progressively narrowing the gap between single photon emission tomography (SPECT) and PET. Ultra-fast SPECT cameras with sub-millimetre resolutions are expected to replace old cameras, thus opening tantalizing clinical opportunities for technetium-99m diagnostic agents. In this scenario, in order to fully exploit the huge potential of these new technologies, unprecedented categories of technetium complexes might be required. Therefore, it seems worthy to review the status of technetium chemistry and to summarize the most remarkable results that have been unearthed during the last years. The aim of this Special Issue is to collect a number of contributions that can illustrate the still-flourishing field of technetium coordination chemistry and its applications to diagnostic medicine.

Prof. Dr. Adriano Duatti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • technetium
  • technetium-99m
  • coordination complexes
  • technetium chemistry
  • metallic functional groups
  • radiometals
  • radiopharmaceuticals
  • imaging agents
  • SPECT

Published Papers

This special issue is now open for submission.
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