Special Issue "Recent Breakthroughs in Technetium Chemistry"
Deadline for manuscript submissions: 31 August 2019.
The first ever discovered artificial element, technetium, has played a pivotal role in promoting the growth and remarkable success of nuclear diagnostic imaging in the past decades. Actually, a group of radiopharmaceuticals labelled with the gamma-emitting radioisotope technetium-99m are still employed as standard imaging agents in the routine clinical practice of different medical specialties, ranging from cardiology to oncology, for the diagnosis of a number of diseases. Despite current overwhelming emphasis on positron emission tomography (PET), it is interesting to note that one of the first-line approaches for the assessment of coronary artery disease (CAD) is still based on the use of technetium-99m myocardial imaging agents, the impact of PET tracers in this field being still limited. It is easy to recognize that the most important reason for this long-lasting success of technetium-99m radiopharmaceuticals resides in the richness of the chemistry of this transition element. Only the existence of a multitude of stable chemical motifs and structural arrangements for technetium complexes has allowed investigation of the biological and diagnostic properties of a large spectrum of coordination compounds and eventually the discovery of useful imaging agents. Thus, the study of the inorganic chemistry of technetium has been at the root of the success of this class of radiopharmaceuticals.
Today, we are at the verge of a new era for technetium-99m radiopharmaceuticals after many years of obscurity. New outstanding technological developments are progressively narrowing the gap between single photon emission tomography (SPECT) and PET. Ultra-fast SPECT cameras with sub-millimetre resolutions are expected to replace old cameras, thus opening tantalizing clinical opportunities for technetium-99m diagnostic agents. In this scenario, in order to fully exploit the huge potential of these new technologies, unprecedented categories of technetium complexes might be required. Therefore, it seems worthy to review the status of technetium chemistry and to summarize the most remarkable results that have been unearthed during the last years. The aim of this Special Issue is to collect a number of contributions that can illustrate the still-flourishing field of technetium coordination chemistry and its applications to diagnostic medicine.
Prof. Dr. Adriano Duatti
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- coordination complexes
- technetium chemistry
- metallic functional groups
- imaging agents