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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies

edited by

Ovidiu Simion Cotoi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 15777 | Submission Open

Keywords: skin cancer; melanoma; non-melanoma; immunotherapy; cutaneous malignancies; targeted therapy; early detection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases Research and Therapy—Third Edition

edited by

Sumonto Mitra

submission deadline 20 Aug 2025 | 7 articles | Viewed by 15026 | Submission Open

Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Cytokines in Inflammatory Signaling: 2nd Edition

edited by

Waipo Chong

Daniela Novick

and

Rosalinda Sorrentino

submission deadline 20 Aug 2025 | 7 articles | Viewed by 14830 | Submission Open

Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0

edited by

Zsuzsanna Helyes

and

Szőke Éva

submission deadline 20 Aug 2025 | 5 articles | Viewed by 14308 | Submission Open

Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostics and Genomics of Tumors

edited by

Petra Korać

submission deadline 20 Aug 2025 | 9 articles | Viewed by 13772 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Photodynamic Therapy and Photodetection, 2nd Edition

edited by

Petras Juzenas

submission deadline 20 Aug 2025 | 11 articles | Viewed by 13104 | Submission Open

Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Targeted Therapies and Drugs in Cancer

edited by

Maria Teresa Vietri

submission deadline 20 Aug 2025 | 5 articles | Viewed by 13101 | Submission Open

Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise and Health: Cellular and Molecular Perspectives

edited by

Annamaria Mancini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 13063 | Submission Open

Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise

(This special issue belongs to the Section Molecular Biology)

Molecular Pathophysiology of Lung Diseases

edited by

Theodoros Karampitsakos

and Brenda M. Juan-Guardela

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12702 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19 interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Approach to Fern Development

edited by

Helena Fernández

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12182 | Submission Open

Keywords: apomixis; apogamy; asexual reproduction; fern; proteomics; genomics; plant development; evo-devo; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Biomedical Applications of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 20 Aug 2025 | 6 articles | Viewed by 11819 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage

(This special issue belongs to the Section Molecular Pharmacology)

Plant Responses to Abiotic and Biotic Stresses

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Aug 2025 | 15 articles | Viewed by 11667 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition

edited by

Claudia Ricci

submission deadline 20 Aug 2025 | 7 articles | Viewed by 11563 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Epigenetic Genes, Biomarkers and Immunotherapy in Cancers

edited by

Urszula Oleksiewicz

and

Andrzej Mackiewicz

submission deadline 20 Aug 2025 | 5 articles | Viewed by 11399 | Submission Open

Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses

(This special issue belongs to the Section Molecular Oncology)

Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways

edited by Ralf Herwig

submission deadline 20 Aug 2025 | 6 articles | Viewed by 11276 | Submission Open

Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Advances in Endometriosis Research: 3rd Edition

edited by

Antonio Simone Laganà

submission deadline 20 Aug 2025 | 3 articles | Viewed by 11216 | Submission Open

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 20 Aug 2025 | 10 articles | Viewed by 11188 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Epigenetic Modifications

edited by

Marco Miceli

, Mariella Cuomo and

Rosa Della Monica

submission deadline 20 Aug 2025 | 4 articles | Viewed by 11166 | Submission Open

Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development

(This special issue belongs to the Section Molecular Genetics and Genomics)

Viral Infection and Virology Methods

edited by

Letizia Santinelli

submission deadline 20 Aug 2025 | 6 articles | Viewed by 11165 | Submission Open

Keywords: acute and chronic viral infection; molecular mechanism; new methodologies; emerging disease; innate and adaptive immunity

(This special issue belongs to the Section Molecular Microbiology)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine

edited by

Giovanni Ventura

submission deadline 20 Aug 2025 | 8 articles | Viewed by 11032 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolimics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Novel Therapeutic Targets in Cancers: 3rd Edition

edited by

Elena Levantini

submission deadline 20 Aug 2025 | 5 articles | Viewed by 11004 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

New Insights into CKD and Age-Related Bone and Mineral Disorders

edited by

Natalia Carrillo-López

Sara Panizo

and

Cristina Alonso-Montes

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10890 | Submission Open

Keywords: chronic kidney disease; CKD; CKD-MBD; mineral and bone disorder

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Regulation in Chronic Kidney Diseases

edited by

Marijn Speeckaert

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10681 | Submission Open

Keywords: chronic kidney disease; pathophysiology; genetic and epigenetic factors; metabolic and inflammatory pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Glycosaminoglycans in Human Diseases

edited by

Darko Kero

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10638 | Submission Open

Keywords: glycosaminoglycans; inflammation; infectious disease; cancer

(This special issue belongs to the Section Biochemistry)

Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights

edited by

Ramona Suharoschi

Oana Lelia Pop

and

Adriana Fodor

submission deadline 20 Aug 2025 | 3 articles | Viewed by 10628 | Submission Open

Keywords: phytochemicals; antioxidant activities; anti-inflammatory properties; antimicrobial effects; molecular mechanisms; clinical applications; traditional medicine; bioavailability; safety and toxicology and regulatory aspects of phytochemicals; pharmacological interaction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neurological Disorders: Molecular Pathology and Therapeutic Approaches

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Aug 2025 | 4 articles | Viewed by 10511 | Submission Open

Keywords: The following topics are proposed for this SI:Intracellular signalling networks in neurological disorders.Identification of new therapeutic targets.Genetics of neurological disorders: identification and treatment of mutations.Mitochondrial diseases and neurodegeneration.Gene therapy in neurological diseases: recent advances.Neuroinflammation in autoimmune disorders of the central nervous system.Impact of the microbiome on neurological health.

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pharmacology in Diabetes, 2nd Edition

edited by

Rosa Fernandes

and

Flávio Reis

submission deadline 20 Aug 2025 | 3 articles | Viewed by 10254 | Submission Open

Keywords: diabetes; vascular complications; cancer; neurodegenerative disorders; key molecular players; signaling pathways; molecular biomarkers; pharmacological agents; antioxidants; anti-inflammatory agents

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research on Protein Structure and Protein Dynamics

edited by

Robert T. Youker

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9664 | Submission Open

Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Calcium Metabolism and Regulation

edited by Hermann Salmhofer and

Michael Lichtenauer

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9657 | Submission Open

Keywords: pathologic calcification; calcification inhibitors; calciprotein particles; Runx-2; apatite; matrix Gla protein; fetuin-A; vitamin D; parathyroid hormone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Study and Treatment of Motor Neuron Diseases

edited by Simona Rossi and

Savina Apolloni

submission deadline 20 Aug 2025 | 3 articles | Viewed by 9395 | Submission Open

Keywords: motor neuron; amyotrophic lateral sclerosis; neuronal degeneration; pathogenic mechanisms; molecular therapy

(This special issue belongs to the Section Molecular Neurobiology)

State-of-the-Art Cancer Immunotherapies—2nd Edition

edited by

Takayuki Yoshimoto

Takuma Kato

and

Hisashi Nagase

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9302 | Submission Open

Keywords: immune checkpoint inhibitors; antibody therapy; cytokines/chemokines; CAR-T and TCR-T cells; iPS cell-derived cells; dendritic cell therapy; vaccine; inflammation; mesenchymal stem cells; immunosuppressive tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Molecular and Cellular Research in Ophthalmology

edited by Zala Lužnik Marzidovšek

submission deadline 20 Aug 2025 | 5 articles | Viewed by 9174 | Submission Open

Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy

(This special issue belongs to the Section Molecular Biology)

Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches

edited by

Marlena Brzozowa-Zasada

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9154 | Submission Open

Keywords: gastrointestinal cancer; molecular pathology; innovative therapies; targeted therapy; immunotherapy; cancer resistance

(This special issue belongs to the Section Molecular Oncology)

The Na, K-ATPase in Health and Disease

edited by

Liora Shoshani

submission deadline 20 Aug 2025 | 4 articles | Viewed by 9031 | Submission Open

Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare

edited by

Ion Cristóbal

submission deadline 20 Aug 2025 | 6 articles | Viewed by 9004 | Submission Open

Keywords: prognostic markers; molecular targets; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Rare Diseases Biomarkers: 2nd Edition

edited by

Andrea Bernini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8851 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Immunology and Inflammation During and After Infectious Diseases

edited by

Manuela Ceccarelli

submission deadline 20 Aug 2025 | 5 articles | Viewed by 8849 | Submission Open

Keywords: bacterial infections; fungi infections; HIV; COVID-19; immune response; inflammation

(This special issue belongs to the Section Molecular Immunology)

Biomarkers of Tumor Progression, Prognosis and Therapy: 2nd Edition

edited by

Tibor Krenacs

submission deadline 20 Aug 2025 | 5 articles | Viewed by 8732 | Submission Open

Keywords: cancer biomarkers; genetic aberrations; carcinogenesis; cancer progression; molecular methods; in silico data analysis; image analysis; proteomics

(This special issue belongs to the Section Molecular Oncology)

Recent Advances of Natural Products in Chemical and Biological Aspects

edited by

Francisco Les

Marta Sofía Valero

and

María Pilar Arruebo

submission deadline 20 Aug 2025 | 5 articles | Viewed by 8578 | Submission Open

Keywords: bioactive compounds; polyphenols; antioxidants; natural products; phytochemicals; molecular research; chemical composition; therapeutic targets; action mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Uses of Adult Stem Cells

edited by Leonard M. Eisenberg and Carol A. Eisenberg

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8538 | Submission Open

Keywords: adult stem cells; mesenchymal stem cells; immune response; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy and Cellular Oxidative Stress: Molecular Mechanisms and Diagnostic Biomarkers

edited by Ramona D’Amico and

Daniela Impellizzeri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8512 | Submission Open

Keywords: autophagy; oxidative stress; biomarkers; acute and chronic diseases; molecular pathways; ROS; mitophagy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases

edited by

Pauline Po Yee Lui

submission deadline 20 Aug 2025 | 2 articles | Viewed by 8444 | Submission Open

Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatments in Neurodegenerative Diseases

edited by

Ermanna Turano

and

Raffaella Mariotti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8251 | Submission Open

Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Enzymes for Biotechnological Applications: 2nd Edition

edited by

Salvatore Fusco

submission deadline 20 Aug 2025 | 3 articles | Viewed by 8144 | Submission Open

Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering

(This special issue belongs to the Section Biochemistry)

Plant-Derived Food Products in the Prevention of Chronic Non-Communicable Diseases

edited by

Teresa Leszczyńska

Barbara Borczak

and

Joanna Kapusta-Duch

submission deadline 20 Aug 2025 | 6 articles | Viewed by 8086 | Submission Open

Keywords: plant foods; plant-derived foods; oxidative stress; bioactive compounds; antioxidative substances; chronic non-communicable diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms and Treatments of Organ Hypoxia or Ischemia

edited by

Athanasios Lourbopoulos

and

Iordanis Mourouzis

submission deadline 20 Aug 2025 | 4 articles | Viewed by 8004 | Submission Open

Keywords: stroke; myocardial infarction; organ hypoxia; hypoxic molecular mechanisms; secondary hypoxia; inflammatory hypoxia; translational studies; diagnostic; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurodegenerative Diseases: New Insights into Mechanisms, Prevention, Markers, and Therapeutic Targets

edited by

Katarzyna Kaczyńska

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7909 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; molecular targets; biomarkers; disease modeling; therapeutic strategies; prevention; drug design

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Strategies to Target Metabolism, Inflammation, and Oxidative Stress in Human Diseases

edited by

Kota V. Ramana

submission deadline 20 Aug 2025 | 7 articles | Viewed by 7870 | Submission Open

Keywords: metabolism; inflammation; oxidative stress; diabetes; aging; cardiovascular diseases; gene editing; stem cell therapy; next-generation sequencing; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 20 Aug 2025 | 3 articles | Viewed by 7816 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Functional and Structural Genomics Studies for Plant Breeding

edited by

Andrea Cavallini

, Tommaso Giordani and Alberto Vangelisti

submission deadline 20 Aug 2025 | 4 articles | Viewed by 7800 | Submission Open

Keywords: plant transcriptomics; genome sequencing; plant gene function; molecular plant breeding; structural genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 701-750 on page 15 of 68.

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