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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Cardiac Development and Disease (Second Edition)

edited by

Kay-Dietrich Wagner

submission deadline 29 Apr 2026 | Viewed by 146 | Submission Open

Keywords: cardiac development; cardiac repair; regeneration; cardiac cell-cell interaction; fibrosis; remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers, 2nd Edition

edited by

Paola Sena

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1895 | Submission Open

Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Approaches to Asthma Management

edited by

Diego Bagnasco

and

Corrado Pelaia

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1276 | Submission Open

Keywords: severe asthma; type 2 and non-type 2 inflammation; antibodies; comorbidities; treatable traits

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Maternal Effects on Infant Neurodevelopment

edited by

José Antonio Rocha Gontijo

submission deadline 30 Apr 2026 | 1 articles | Viewed by 410 | Submission Open

Keywords: maternal– fetal interactions; epigenetic regulation; neurodevelopmental programming; placental signaling; glucocorticoid receptors; brain-derived neurotrophic factor (BDNF); oxidative stress; synaptic plasticity; perinatal stress; corticotropin-releasing factor (CRF) pathway

(This special issue belongs to the Section Molecular Neurobiology)

Deciphering the Molecular Symphony of Microbiome-Driven Immune Modulation

edited by Edda Russo and

Sara Salvetti

submission deadline 30 Apr 2026 | Viewed by 388 | Submission Open

Keywords: microbiome; immune; microbial-host interactions

(This special issue belongs to the Section Molecular Immunology)

Computer Simulation Insight into Ligand–Receptor Interaction

edited by

Antonios Drakopoulos

submission deadline 30 Apr 2026 | Viewed by 245 | Submission Open

Keywords: structure– activity relationship (SAR); free energy perturbation (FEP); structure-based drug design (SBDD); machine learning in drug discovery; hybrid qm/mm methods; binding affinity prediction; enhanced sampling techniques; target binding kinetics

(This special issue belongs to the Section Molecular Informatics)

Design, Synthesis, and Applications of Advanced Functional Materials

edited by

Angelika Kmita

submission deadline 30 Apr 2026 | Viewed by 193 | Submission Open

Keywords: advanced functional materials; materials synthesis; nanomaterials; hybrid materials

(This special issue belongs to the Section Materials Science)

Human Meningioma: Recent Developments

edited by Jason P. Sheehan, Yuki Shinya and Stylianos Pikis

submission deadline 30 Apr 2026 | Viewed by 191 | Submission Open

Keywords: meningioma; molecular pathogenesis; genomic alteration; radiogenomics; tumor microenvironment; biomarkers; neurosurgery; radiosurgery; translational neuroscience; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Exploring Molecular Progression in Inorganic Synthesis

edited by

Suraj Kumar Pathak

submission deadline 30 Apr 2026 | Viewed by 173 | Submission Open

Keywords: inorganic synthesis; materials science; catalysis; energy materials; bioinorganic systems; organometallic compounds; supramolecular chemistry; molecular design

(This special issue belongs to the Section Materials Science)

Transition-Metal-Based Nanoparticles: Synthesis, Properties and Applications

edited by Ramin Yousefi and

Sasan Rezaee

submission deadline 30 Apr 2026 | Viewed by 164 | Submission Open

Keywords: transition metal nanoparticles; synthesis; structure– property relationship; catalysis; photocatalysis; energy storage and conversion; biomedical applications; drug delivery; environmental remediation; plasmonics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Targeted Therapy and Epigenetic Advances in Cancer

edited by Qing Sheng Mi and

Li Zhou

submission deadline 30 Apr 2026 | Viewed by 152 | Submission Open

Keywords: cancer; epigenetic; therapeutic targets; chromatin; DNA methylation; histone modification; noncoding RNA; histone variants

(This special issue belongs to the Section Molecular Oncology)

Phytochemicals for Diabetes

edited by

Cosmin Mihai Vesa

submission deadline 30 Apr 2026 | Viewed by 151 | Submission Open

Keywords: phytochemicals; diabetes mellitus; insulin resistance; oxidative stress; inflammation; plant extracts; polyphenols; flavonoids; nutraceuticals; diabetic complications

(This special issue belongs to the Section Molecular Pharmacology)

Focus on Heterocyclic Compounds and Their Various Applications

edited by

Georgia Zissimou

submission deadline 30 Apr 2026 | Viewed by 141 | Submission Open

Keywords: heterocyclic compounds; heterocyclic organic synthesis; medicinal heterocycles; bioactive heterocycles; heterocycles in materials sciences

(This special issue belongs to the Section Biochemistry)

Molecular Research in Hepatic Amino Acid Catabolism

edited by Carolina Conter

submission deadline 30 Apr 2026 | Viewed by 140 | Submission Open

Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Natural Compounds: Impact on Health and Disease

edited by

Jaehoon Bae

submission deadline 30 Apr 2026 | Viewed by 131 | Submission Open

Keywords: natural compounds; bioactive molecules; disease prevention; phytochemicals; functional food; molecular mechanisms; therapeutic potential; oxidative stress; immune modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genome Editing in Disease Research: Applications in Animal Models and Organoids

edited by

Timofey S. Rozhdestvensky

submission deadline 30 Apr 2026 | Viewed by 130 | Submission Open

Keywords: genome editing; CRISPR/Cas; disease modeling; functional genomics; organoids

(This special issue belongs to the Section Molecular Biology)

The Impact of Oxidative Stress on Male and Female Germ Cells: From Redox Biology to Photon Emission

edited by

József Bódis

submission deadline 30 Apr 2026 | Viewed by 130 | Submission Open

Keywords: oxidative stress; germ cells; fertility; redox signaling; mitochondrial dynamics; DNA damage; photonic communication; ultra-weak photon emission; quantum biology; reproductive health

(This special issue belongs to the Section Biochemistry)

Dysfunctional Neural Circuits and Impairments in Brain Function, 2nd Edition

edited by

Takashi Tominaga

and

Ichiro Takashima

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: neural circuits; dysfunctional circuits; neuropsychiatric disorders; optical recording; voltage-sensitive dyes; genetically encoded optical indicators; local brain activity; whole-brain activity; cognitive impairments; behavioral test

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 30 Apr 2026 | Viewed by 109 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic, Transcriptomic, and Epigenetic Approaches in Fish Research

edited by

Feng Liu

submission deadline 30 Apr 2026 | Viewed by 106 | Submission Open

Keywords: fish biology; omics technologies; genomics and transcriptomics; environmental adaptation; aquaculture traits

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Nutrient Uptake and Utilization in Plants

edited by

Stella Karydogianni

submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open

Keywords: agriculture and crop improvement; molecular and cellular mechanisms; nitrogen; nutrient efficiency; protein

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Cellular Mechanism in Amyotrophic Lateral Sclerosis

edited by Nilo Riva

submission deadline 30 Apr 2026 | Viewed by 104 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron vulnerability; TDP-43; axonal degeneration; proteinopathy; stress granules; C9orf72; SOD1; RNA metabolism; FTD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Immunodeficiency and Immunotherapy in Multiple Myeloma

edited by

Marjorie Pick

and

Eyal Lebel

submission deadline 30 Apr 2026 | Viewed by 97 | Submission Open

Keywords: multiple myeloma; plasma cells; monoclonality; immunodeficient

(This special issue belongs to the Section Molecular Immunology)

The Latest Research on Molecular Studies of Crustaceans

edited by

Xianliang Meng

and

Yafei Duan

submission deadline 30 Apr 2026 | 1 articles | Viewed by 91 | Submission Open

Keywords: crustacean; molecular; genetics; physiology; ecology; environmental

(This special issue belongs to the Section Molecular Biology)

Peptides in Healthcare and Beyond: Emerging Roles in Skincare, Nutrition, Medicine, and Animal Health

edited by

Jiazhong Li

and Lijing Fang

submission deadline 30 Apr 2026 | Viewed by 89 | Submission Open

Keywords: peptides; efficacy; healthcare; skincare; nutrition; medicine; animal health

(This special issue belongs to the Section Biochemistry)

Mitochondrial Signaling Pathways in Inflammation and Diseases

edited by

Francesca Oppedisano

and

Cristina Algieri

submission deadline 30 Apr 2026 | Viewed by 89 | Submission Open

Keywords: mitochondria; cell metabolism; inflammatory mitochondrial signalling; metabolic pathways; mitochondrial dysfunction; mtDNA; cGAS-STING pathway; NLRP3 inflammasome; human pathology

(This special issue belongs to the Section Biochemistry)

Gut Microbiota-Derived Metabolites in Human Health and Disease

edited by Zeneng Wang

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: microbiome; microbiota; gut; metabolomics; health; disease; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Emerging Topics in Polymeric Nanoparticles

edited by

Andrei Honciuc

and

Mirela Honciuc

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials

(This special issue belongs to the Section Macromolecules)

Gene Therapy for Ocular Diseases: Mechanisms, Advances and Therapeutic Applications

edited by Jiang-Hui Wang

submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open

Keywords: AAV; capsid engineering; gene therapy; retinal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Next-Generation CRISPR and Gene Editing Tools

edited by

Oscar Pérez-Leal

submission deadline 30 Apr 2026 | Viewed by 80 | Submission Open

Keywords: CRISPR engineering; miniaturized CRISPR; gene editing delivery; prime editing; base editing; epigenome editing; single-cell CRISPR

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cariovascular Diseases: From Molecular Mechanisms to Therapeutics

edited by

Paul Quax

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: yocardial infarction and cardiac regeneration; microvasculature in cardiovascular health and disease; gender specific aspects of cardiovascular disease; heart failure; aneurysm formation and dissection; vascular remodeling (restenosis; atherosclerosis; angioegenesis); valve failure; replacement or regeneration; atherosclerosis; imaging; new therapeutic options including non-coding RNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles – New Kids on the Block in Liquid Biopsy

edited by Christa Nöhammer

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: extracellular vesicles; biological fluids; liquid biopsy; multi-omics; biomarkers; EV technologies

(This special issue belongs to the Section Molecular Biology)

Next-Generation Antimicrobials and Anticancer Agents: From Natural to Synthetic Compounds

edited by

Manuela E. Crisan

and Roxana Popescu

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: bioactive molecules; natural products; synthetic compounds; molecular design; antimicrobial agents; anticancer agents; drug-resistant infections; drug discovery

(This special issue belongs to the Section Biochemistry)

Green Synthesis of Biomaterials Using Plant Extracts with Potential Application in Medicine and Biotechnology

edited by

Divine Yufetar Shyntum

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: green synthesis; biomaterials; antimicrobial activity; plant-mediated green synthesis; biomedical application; antibiotic resistance

(This special issue belongs to the Section Materials Science)

Regulatory Mechanism and Network of Abiotic Stress-Response in Plants: 3rd Edition

edited by

Yong-Hwan Moon

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

Impact of Exercise on Molecular and Cellular Processes in the CNS

edited by

Philippe De Deurwaerdere

and Hélène Gréa

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: physical exercise; plasticity; neurotransmission; metabolism; neuroinflammation; glia; epigenetic; CNS disease; animal models; humans

(This special issue belongs to the Section Molecular Biology)

Novel Therapeutic Targets in Cancers: 4th Edition

edited by

Elena Levantini

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights and Therapeutic Innovations in Neuromuscular Diseases

edited by

Virginia Arechavala Gomeza

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: neuromuscular disorders; molecular mechanisms; gene therapies; RNA therapies; small molecules

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 30 Apr 2026 | Viewed by 69 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 3rd Edition

edited by

Jarosław Nuszkiewicz

and

Alina Woźniak

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: oxidative stress; redox homeostasis; reactive oxygen species (ROS); redox signaling; antioxidants and defense mechanisms; metabolic regulation; inflammation and redox imbalance; mitochondrial dysfunction; biomarkers of oxidative stress; therapeutic redox modulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular, Genetic and Genomic Insights into Marine Organisms: From Mechanisms to Ecology

edited by Yaron Tikochinski

submission deadline 30 Apr 2026 | Viewed by 66 | Submission Open

Keywords: marine genomics; molecular ecology; population genetics; transcriptomics; conservation genomics; eDNA; functional genomics; environmental stress; phylogeography; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bone Health: From Molecular Mechanisms to Therapeutics

edited by

Farasat Zaman

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: bone growth; chondrocytes; osteoporosis; fractures; inflammation; cancer; nutrition; stress; biomechanics; biotechnology; bioengineering

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Zebrafish Model in Animal and Human Health Research, 3rd Edition

edited by

Marta Anna Szychlinska

and Federica Scalia

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: zebrafish; environmental toxicology; predictive toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Microplastics, Gut Microbiome and Human Health

edited by

Ying Zhang

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: microplastics; gut microbiome; dysbiosis; intestinal barrier; immunotoxicity; metabolic inflammation; na-noplastics; molecular mechanisms

Molecular Mechanisms of Plant-Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

New Insights in Antibiotic Resistance/Tolerance

edited by

Mara Di Giulio

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: antibiotic resistance; biofilm; innovative antimicrobial strategies and compounds; synergistic actions; One Health; bacterial tolerant phenotypes; resistant pathogenic microorganisms; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 3001-3050 on page 61 of 69.

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