Zebrafish as a Model for Neurological Disorders

Dear Colleagues,

During the last decade, thanks to huge progress in molecular biology tools and techniques, including gene editing, neuron calcium imaging and behaviour-recording automates, the zebrafish (Danio rerio) has become one of the most widely used animal model in biological sciences, not only to investigate the processes underlying the pathophysiology of a large variety of human disorders, including neuronal diseases, but also identify molecules with therapeutic properties. Zebrafish larvae are especially powerful and useful for experimental research, because of their small size, rapid development and transparency, which make them particularly suited for in vivo imaging studies. In addition, as a vertebrate, the zebrafish genome shows high levels of similarity when compared to the human genome with more than 80% of human disease genes found in zebrafish, making this species a unique and powerful tool to investigate the core mechanisms of disease pathogenesis.

This Special Issue attempts to illustrate the contribution of the zebrafish as models of human neurological diseases and welcomes original research or review papers highlighting the power and interest of this small and easy breeding fish to study several neurological disorders and to identify therapeutic tools for these diseases. Papers should be supported by sufficient data or evidence.

Dr. Nadia Soussi-Yanicostas
Guest Editor

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