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New insights into the mechanisms of unconventional secretion

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (20 May 2019) | Viewed by 3985

Special Issue Editor

Principal Investigator, Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Box 289 Addenbrooke's Hospital, Cambridge CB2 0QQ, UK

Special Issue Information

Dear Colleagues,

Eukaryotic cells have a highly-evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases, including cancer, metabolic diseases and neurological disorders. Most proteins are secreted using the endoplasmic reticulum/Golgi network. However, several proteins are secreted by unconventional transport pathways. Summarizing 20 years of research, protein families with members that use this pathway include annexins, glycolytic enzymes, heat shock proteins, interleukins, fibroblast growth factors, galectins, transglutaminases and misfolded proteins among many others. This illustrates that unconventional secretion is a diverse and heterogeneous field. Over the years, the extracellular functions of these proteins have been well documented. Yet, the mechanisms of secretion and its regulation remain poorly uncharacterized. In this special edition, we will discuss the recent findings on the mechanisms of unconventional secretion and its implications in health and diseases.

Dr. Kevin Moreau
Guest Editor

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Keywords

  • unconventional secretion
  • protein and membrane trafficking
  • pore
  • protein folding
  • lipid remodelling

Published Papers (1 paper)

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Review

13 pages, 1096 KiB  
Review
A Potential Lock-Type Mechanism for Unconventional Secretion in Fungi
by Michèle Reindl, Sebastian Hänsch, Stefanie Weidtkamp-Peters and Kerstin Schipper
Int. J. Mol. Sci. 2019, 20(3), 460; https://doi.org/10.3390/ijms20030460 - 22 Jan 2019
Cited by 27 | Viewed by 3739
Abstract
Protein export in eukaryotes can either occur via the classical pathway traversing the endomembrane system or exploit alternative routes summarized as unconventional secretion. Besides multiple examples in higher eukaryotes, unconventional secretion has also been described for fungal proteins with diverse functions in important [...] Read more.
Protein export in eukaryotes can either occur via the classical pathway traversing the endomembrane system or exploit alternative routes summarized as unconventional secretion. Besides multiple examples in higher eukaryotes, unconventional secretion has also been described for fungal proteins with diverse functions in important processes such as development or virulence. Accumulating molecular insights into the different export pathways suggest that unconventional secretion in fungal microorganisms does not follow a common scheme but has evolved multiple times independently. In this study, we review the most prominent examples with a focus on the chitinase Cts1 from the corn smut Ustilago maydis. Cts1 participates in cell separation during budding growth. Recent evidence indicates that the enzyme might be actively translocated into the fragmentation zone connecting dividing mother and daughter cells, where it supports cell division by the degradation of remnant chitin. Importantly, a functional fragmentation zone is prerequisite for Cts1 release. We summarize in detail what is currently known about this potential lock-type mechanism of Cts1 secretion and its connection to the complex regulation of fragmentation zone assembly and cell separation. Full article
(This article belongs to the Special Issue New insights into the mechanisms of unconventional secretion)
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