New insights into the mechanisms of unconventional secretion
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (20 May 2019) | Viewed by 4900
Special Issue Editor
Special Issue Information
Dear Colleagues,
Eukaryotic cells have a highly-evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases, including cancer, metabolic diseases and neurological disorders. Most proteins are secreted using the endoplasmic reticulum/Golgi network. However, several proteins are secreted by unconventional transport pathways. Summarizing 20 years of research, protein families with members that use this pathway include annexins, glycolytic enzymes, heat shock proteins, interleukins, fibroblast growth factors, galectins, transglutaminases and misfolded proteins among many others. This illustrates that unconventional secretion is a diverse and heterogeneous field. Over the years, the extracellular functions of these proteins have been well documented. Yet, the mechanisms of secretion and its regulation remain poorly uncharacterized. In this special edition, we will discuss the recent findings on the mechanisms of unconventional secretion and its implications in health and diseases.
Dr. Kevin Moreau
Guest Editor
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Keywords
- unconventional secretion
- protein and membrane trafficking
- pore
- protein folding
- lipid remodelling
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