Regulation of Substrate Metabolism for Energy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 15467
Special Issue Editor
Interests: differential metabolism of glucose isoforms; glucocorticoid control of liver glucose production and glycolytic disposal; testosterone and control of body glucose levels and utilization; estrogens and sex differences in 3c metabolites and fatty acid metabolism
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Special Issue Information
Dear Colleagues,
Most nutrients are eventually used for energy (including body components’ turnover), and only (especially in growing subjects) part of them is used to build up new living tissue. There are many studies devoted to analyzing the fate of metabolic substrates derived from an extensive variety of nutrients, and, in particular, to analyzing the effects of the modulation of feeding on whole body composition and related disorders. In parallel, there are extensive studies on the regulation of the metabolism of specific substrates and their conversion to energy, both at the cell and organ levels. Notwithstanding, these lines of study leave a considerable gap at the converging node of global (i.e., whole body) adjustments to varying substrate availability and the regulation of their utilization at the molecular physiology level. Filling this gap is critical to understand how overall energy homeostasis is maintained, and how a regulatory equilibrium between substrate diverse quantitative and qualitative availability is corrected to maintain energy homeostasis. This central regulation of substrate fluxes (carbohydrates, fatty acids and amino acids, essentially) to maintain energy availability despite fluctuations in their supply has become essential to understand (and eventually correct) widely extended metabolic/functional disorders: from malnutrition to metabolic syndrome.
Dr. Marià Alemany
Guest Editor
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Keywords
- substrates and energy partition
- dietary nutrients
- amino acid oxidation
- lipid oxidation
- lipid accrual
- adipose tissue
- glucose and 3C utilization
- malnutrition
- cachexia
- metabolic syndrome
- obesity
- inter-organ substrate fluxes
- regulation of energy metabolism
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