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Reproductive Immunology: Cellular and Molecular Biology 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 4505

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Greece
Interests: implantation; receptivity; endometrium; RIF; early pregnancy; trophoblast
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue on “Reproductive Immunology: Cellular and Molecular Biology 2.0”.

Reproductive immunology in the 21st century still deals with a problem that has been known for decades—the fetus as semi-allograft and its response to the maternal immune system. Therefore, there is a strong need to solve problems such as spontaneous and recurrent miscarriages and, in addition, repeated implantation failure.
Furthermore, socioeconomical changes in an aging society are an additional challenge especially for the reproductive medicine specialist. Although highly developed in vitro fertilization techniques are available, many couples still face the problem of childlessness.
A quite new player in the field is the microbiome of the reproductive tract. For decades, it was believed that the uterus is sterile but an up to date analysis revealed that we not only have a vaginal microbiome but also a cervical, uterine, male, and even a placental microbiome.
Therefore, we would like to invite our colleagues to submit articles that deal with cellular and molecular mechanisms in the field of reproductive immunology to this Special Issue.

Prof. Dr. Udo Jeschke
Prof. Dr. Antonis Makrigiannakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spontaneous and recurrent miscarriage
  • repeated implantation failure
  • maternal immune cells
  • microbiome
  • assisted reproduction

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Published Papers (2 papers)

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Research

15 pages, 1601 KiB  
Article
Semen Protein CRISP3 Promotes Reproductive Performance of Boars through Immunomodulation
by Yonghui Bu, Ping Wang, Siqi Li, Li Li, Shouquan Zhang and Hengxi Wei
Int. J. Mol. Sci. 2024, 25(4), 2264; https://doi.org/10.3390/ijms25042264 - 14 Feb 2024
Viewed by 862
Abstract
Semen proteins play an important role in male reproductive performance and sperm fertilization ability and can be used as potential biomarkers to evaluate male fertility. The role of cysteine-rich secretory protein 3 (CRISP3) in male reproduction remains unknown. This study aimed to investigate [...] Read more.
Semen proteins play an important role in male reproductive performance and sperm fertilization ability and can be used as potential biomarkers to evaluate male fertility. The role of cysteine-rich secretory protein 3 (CRISP3) in male reproduction remains unknown. This study aimed to investigate the role of CRISP3 in the reproductive performance of boars. Our results showed that the CRISP3 protein content was significantly and positively correlated with boar fertility, sow delivery rate, and litter size. CRISP3 is highly expressed in the bulbourethral gland of adult boars and is enriched in the seminal plasma. It is localized in the post-acrosomal region of the sperm head and migrates to the anterior end of the tail after capacitation. The CRISP3 recombinant protein did not affect sperm motility and cleavage rate, but it significantly downregulated the mRNA expression of inflammatory factors IL-α, IL-1β, and IL-6 and the protein expression of IL-α and IL-6 in lipopolysaccharide (LPS)-induced RAW264.7 cells, indicating that CRISP3 has an immunomodulatory function. In conclusion, our study suggests that semen CRISP3 protein levels positively correlate with reproductive performance, which may be achieved by regulating immune responses in the female reproductive tract. Full article
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 3.0)
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16 pages, 3261 KiB  
Article
Examination of the TIGIT-CD226-CD112-CD155 Immune Checkpoint Network during a Healthy Pregnancy
by Matyas Meggyes, David U. Nagy, Timoteus Feik, Akos Boros, Beata Polgar and Laszlo Szereday
Int. J. Mol. Sci. 2022, 23(18), 10776; https://doi.org/10.3390/ijms231810776 - 15 Sep 2022
Cited by 7 | Viewed by 2808
Abstract
Background: The importance of immune checkpoint molecules is well known in tumor and transplantation immunology; however, much less information is available regarding human pregnancy. Despite the significant amount of information about the TIGIT and CD226 immune checkpoint receptors in immune therapies, very little [...] Read more.
Background: The importance of immune checkpoint molecules is well known in tumor and transplantation immunology; however, much less information is available regarding human pregnancy. Despite the significant amount of information about the TIGIT and CD226 immune checkpoint receptors in immune therapies, very little research has been conducted to study the possible role of these surface molecules and their ligands (CD112 and CD155) during the three trimesters of pregnancy. Methods: From peripheral blood, immune cell subpopulations were studied, and the surface expression of immune checkpoint molecules was analyzed by flow cytometry. Soluble immune checkpoint molecule levels were measured by ELISA. Results: Notable changes were observed regarding the percentage of monocyte subpopulation and the expression of CD226 receptor by CD4+ T and NKT cells. Elevated granzyme B content by the intermediate and non-classical monocytes was assessed as pregnancy proceeded. Furthermore, we revealed an important relationship between the CD226 surface expression by NKT cells and the serum CD226 level in the third trimester of pregnancy. Conclusions: Our results confirm the importance of immune checkpoint molecules in immunoregulation during pregnancy. CD226 seems to be a significant regulator, especially in the case of CD4+ T and NKT cells, contributing to the maternal immune tolerance in the late phase of pregnancy. Full article
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology 3.0)
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