Special Issue "Bacterial Protein Toxins: Enemies within or Unexpected Friends"
Deadline for manuscript submissions: closed (31 January 2019).
Interests: bacterial protein toxins; Rho GTPases; cytoskeleton; mitochondria; cancer; toxins as therapeutics
Special Issues and Collections in MDPI journals
Bacterial protein toxins are the principal virulence factors of pathogenic bacteria and their production represents one of the main bacterial strategies to interact with mammalian cells. Using diverse and sophisticated mechanisms, bacterial toxins manipulate the host cell functions to suit their own needs, favoring the spreading, colonization, and survival of the microbes. However, toxins play a negative role in human health, not only because implicated in infectious diseases but also because potentially involved in harmful situations, such as cancer development. Under all these aspects, bacterial toxins can certainly be considered as “enemies”.
On the other hand, knowledge of their modes of action has permitted their beneficial use, not only as high selective tools in cell biology, but also as potential new drugs for medical applications. For example, some toxins can be “engineered” as the cell-killing component of immuno-toxins, while others toxins or their derivatives have been incorporated into human vaccines because of their adjuvant properties. Paradigmatic is the use of botulinum toxin, the most powerful candidate as a biological weapon, which is used for human disorders characterized by hyperactivity of nerve terminals of whatever origin and is today very popular for its ability to reduce wrinkles. Thus, the scientific research has permitted to convert these harmful bacterial molecules into “friends”.
In this Special Issue of IJMS, the focus will be on bacterial protein toxins pointing to both their pathogenetic strategies and their therapeutic potentials, thus highlighting the Janus aspect of such virulence factors.
Dr. Carla Fiorentini
Dr. Alessia Fabbri
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- bacterial protein toxins
- molecular target
- drug discovery