Modulation of Protein Structure and Function by Lipids
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 18418
Special Issue Editor
Interests: structure–function relationship in proteins; protein–lipid interactions; lipid modulation of protein function; modulation of ion channel function; atrial and neuronal G protein-gated inwardly rectifying potassium channels; cholesterol; phosphoinositides; fatty acids
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Special Issue Information
Dear Colleagues,
Since the introduction of the fluid mosaic model of cell membrane structure by Singer and Nicolson in 1972, our understanding of the roles of lipids in cellular functions has evolved significantly. Through insights gained with advances in technology, it has become clear that lipids are not merely passive entities that diffuse freely within membrane bilayers but are also key players in the modulation of protein function. Lipids, such as phosphoinositides, sterols, and fatty acids, have been shown to affect the function of a growing number of proteins (e.g., G protein-coupled receptors, ion channels, transporters, etc.). Lipids exert their effect on proteins through a variety of mechanisms, such as by modulating protein structure, function, and dynamics; promoting protein oligomerization; and mediating protein–protein interactions in the membrane. As a result, lipids have emerged as central players in diverse disease processes and, hence, in drug development, where lipid-regulated proteins are potential drug targets. The aim of this Special Issue is to provide an overview of the current understanding of the impact of lipids on protein structure and function in addition to presenting new developments in this field. Both original papers and reviews on this topic are welcome.
Dr. Avia Rosenhouse-Dantsker
Guest Editor
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Keywords
- protein modulation by lipids
- phosphoinositides
- cholesterol
- sterols
- fatty acids
- G protein-coupled receptors
- ion channels
- transporters
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