Protein-Protein and Protein-Ligand Interactions: Current Challenges and Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 4272
Special Issue Editor
Interests: structure; functional interactions; post translational modifications of proteins; NMR spectroscopy; intrinsically disordered proteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Protein–protein and protein–ligand interactions play central roles in all processes of living organisms, participating in their activation and regulation. The identification of the actors of cellular networks based on molecular recognition, as well as the clear definition of the transient and persistent interactions are crucial to elucidate biomolecular communication pathways.
Protein interactions are often at the basis of many pathological states, therefore, their in-depth understanding could open new perspectives in the treatment of many diseases.
A key aspect to advance our knowledge is the availability of reliable novel bioinformatic methods to efficiently predict protein interactions as well as the development and improvement of experimental approaches to fully characterize the structure and thermodynamics of functional biomolecular associations to unveil biologically relevant pathways.
In this Special Issue of IJMS, we aim to collect contributions in the form of either original research articles or reviews, to add new insight into the role of protein–protein and protein–ligand interactions in biological processes and to highlight the state of the art, the challenges, and the open issues in this varied field of investigation.
Dr. Mariapina D'Onofrio
Guest Editor
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Keywords
- Protein interaction networks
- Biological processes
- Protein complexes
- Molecular recognition
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