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Special Issue "Polysaccharides in Drug Delivery"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editors

Dr. Valentino Laquintana
E-Mail Website
Guest Editor
Università degli Studi di Bari, Department of Pharmacy-Drug Sciences, Bari, Italy
Interests: biocompatible polymers; drug delivery systems; drug targeting; micro- and nano-particles; luminescent nanovectors; pro-drugs; mucoadhesive polymers; bioconjugates
Prof. Angela Assunta Lopedota
E-Mail Website
Guest Editor
Department of Pharmacy & Pharmaceutical Sciences, University of Bari “Aldo Moro”, Bari, Italy
Interests: biocompatible polymers; drug delivery systems; drug targeting; micro- and nano-particles; cyclodextrins; mucoadhesive polymers; polysaccharides; thiomers

Special Issue Information

Dear Colleagues,

Polysaccharides embrace a wide class of substances that have attracted considerable attention owing to their desirable physicochemical and biological properties, such as biodegradability, biocompatibility, non-toxicity, as well as non-antigenicity in the fields of nanotechnology, tissue engineering, and drug delivery. Moreover, they possess unique features that can facilitate mucoadhesion, enhanced targeting, and reduced inflammatory response. Polysaccharides are versatile excipients for controlled drug delivery systems. Polymers based on chitosan, alginate, dextran, hyaluronic acid, their derivates, and, moreover, oligosaccharides as cyclodextrins, have been successfully used as biomaterials for the production of nanosystems, surface coating agents, hydrogels, bioconjugates or complexes, and improvement of the toxicity profile and biopharmaceutical properties of drugs. In addition, some polysaccharides are bioactive (i.e., plasma expander dextran, glycosaminiglycans, vaccines). This Special Issue aims to explore the more recent advances in the design of oligo- and poly-saccharides, drug-polymer conjugates, and micro- and nano-carriers dealing with the topics of for drug delivery.

Dr. Valentino Laquintana
Prof. Angela Assunta Lopedota
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Polysaccharides
  • Drug delivery systems
  • Micro- and nano-particles
  • Mucoadhesive polymers
  • Polymeric pro-drugs
  • Cyclodextrins
  • Bioconjugates
  • Hydrogels

Published Papers (1 paper)

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Research

Open AccessArticle
Non-Cytotoxic Agarose/Hydroxyapatite Composite Scaffolds for Drug Release
Int. J. Mol. Sci. 2019, 20(14), 3565; https://doi.org/10.3390/ijms20143565 - 21 Jul 2019
Cited by 2
Abstract
Healing of large bone defects requires implants or scaffolds that provide structural guidance for cell growth, differentiation, and vascularization. In the present work, an agarose-hydroxyapatite composite scaffold was developed that acts not only as a 3D matrix, but also as a release system. [...] Read more.
Healing of large bone defects requires implants or scaffolds that provide structural guidance for cell growth, differentiation, and vascularization. In the present work, an agarose-hydroxyapatite composite scaffold was developed that acts not only as a 3D matrix, but also as a release system. Hydroxyapatite (HA) was incorporated into the agarose gels in situ in various ratios by a simple procedure consisting of precipitation, cooling, washing, and drying. The resulting gels were characterized regarding composition, porosity, mechanical properties, and biocompatibility. A pure phase of carbonated HA was identified in the scaffolds, which had pore sizes of up to several hundred micrometers. Mechanical testing revealed elastic moduli of up to 2.8 MPa for lyophilized composites. MTT testing on Lw35human mesenchymal stem cells (hMSCs) and osteosarcoma MG-63 cells proved the biocompatibility of the scaffolds. Furthermore, scaffolds were loaded with model drug compounds for guided hMSC differentiation. Different release kinetic models were evaluated for adenosine 5′-triphosphate (ATP) and suramin, and data showed a sustained release behavior over four days. Full article
(This article belongs to the Special Issue Polysaccharides in Drug Delivery)
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