Functionalised Self Assembling Peptides in Multi-Component Systems, Biomedical Materials with Added Complexity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 5280
Special Issue Editor
Special Issue Information
Dear Colleagues,
The formation of well-organised assemblies through revisable non-covalent interactions defines the phenomena of self-assembly. The range of structures formed through this process often transcends typical-length scales; basic molecular building blocks can be triggered to form kinetically or thermodynamically stable hierarchical assemblies at the nanoscale, mesoscale, and macroscale, giving rise to novel materials. Indeed, the rational design of peptidic biomolecules that manipulate non-covalent interactions to form these supramolecular structures has given rise to a class of materials for use in regenerative medicine.
Peptide based self-assemblies, inspired by amino acid sequences found in nature, are able to from three dimensional matrices. In an unadulterated form, these matrices have a range of applications within the fields of tissue engineering and regenerative medicine. The ability to control the surface chemistry and the overall nature of the scaffold has yielded well-documented success in these areas. However, combining self-assembling peptides (SAPs) with other moieties or functionalising the SAPs themselves can modify their chemistries and bioactivities, allowing for the development of multi-component systems exhibiting enhanced physical and biological properties that can be utilised for patient benefit.
This Special Issue aims to explore peptide based multi-component systems for use in tissue engineering and regenerative medicine. Papers related to the study and/or applications of self-assembled peptides functionalised with other moieties and their potential biomedical applications are welcomed.
Dr. Robert Philip Wynn Davies
Guest Editor
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Keywords
- Supramolecular assemblies
- Self-assembling peptides
- Multi component systems
- Functionalized peptides
- Scaffolds
- Hydrogels
- Biomimetic
- Biomedical applications
- Hard and soft tissue engineering
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