Special Issue "Neuroinfectiology: Molecular and Cellular Mechanisms of Neurotropic Virus Infection"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 December 2018)
Prof. Dr. Wolfgang Baumgärtner
In recent years, reported cases of viral pathogens causing infection of the central nervous system (CNS) as emerging and re-emerging diseases have been increasingly, particularly noticed in humans and animals. Some viruses will infect only the CNS, others cause systemic spread and affection of the nervous systems and is noticed in a small percentage of individuals. Still, a substantial number of possible viral CNS diseases remain etiologically-undetermined so far. The burden of infectious CNS diseases is reinforced by the fact that survivors may suffer from life-long lasting neurological and psychiatric complications. A sensu stricto definition of neuroinfectiology would refer to a direct pathogen–host cell effect, resulting in cytolysis and inflammation. However, cellular functions may remain impaired despite cell survival especially in the CNS. Such an impaired organ function may be due to a derailment of immune responses, epitope spreading and molecular mimicry, even after elimination of the causing viral pathogen. Similarly, predisposing factors including concurrent diseases, immune deficiencies may increase the susceptibility for viral infection. Therefore, a broader definition of neuroinfectiology should include predisposing mechanisms, acute host–pathogen interactions, as well as long-term, delayed disturbances and disabilities.
Mechanisms that govern neuropathogenesis of viral infections will be highlighted in this Special Issue, entitled “Neuroinfectiology: Molecular and Cellular Mechanisms of Neurotropic Virus Infection”.
Prof. Dr. Wolfgang Baumgärtner
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- acute neuropathogenesis
- long-term pathogenesis
- host-glial cell interactions
- virus discover
- host range
- viral persistence
- delayed neurological symptoms
- neurocognitive disorders
- intervention strategies