Special Issue "Neuroinflammation and Cell Death"
Deadline for manuscript submissions: closed (30 May 2019).
Interests: cerebral ischemia; in vivo and in vitro models; Parkinson's disease; calcium homeostasis; mitochondria; neruonal metabolism; astrocytes; microglia; mitophagy; apoptosis; neurodegeneration; neuroinflammation.. sodium calcium exchangers; transporters; calcium channels
It is well-established that neuroinflammation plays a key pathogenetic role in a broad range of neurological and neurodegenerative disorders including multiple sclerosis, stroke, neoplasia, Parkinson’s Disease, Alzheimer’s Disease, and traumatic brain injury. In addition, an important role of neuroinflammation in the pathophysiology of several neurodegenerative disorders is emerging and becoming an important topic for the prevention and development of disease-modifying treatments. However, whether the neuroinflammatory processes are a cause or a consequence of neuronal degeneration remains unanswered. Characteristic of neuroinflammation is the activation of brain glial cells, principally microglia and astrocytes that release various soluble factors that can, in turn, accelerate the rate of neurodegeneration, synaptic loss, and synaptic dysfunction. On the other hand, there is evidence that activated microglia might also have neuroprotective effects.
This Special Issue of IJMS provides a comprehensive synopsis of the state-of-the-art of neuroinflammation research from cellular to molecular mechanisms, with the aim of delving deeper into unresolved questions about the relationship between markers of neuroinflammation and clinical indices of neurodegeneration, the causal relationship between these two phenomena, and the identification of biomarkers capable of measuring neuroinflammation in vivo, as well as of tracking its course over time, for prognosis and monitoring of effects of disease-modifying therapies.
You are warmly invited to submit original research and review articles related to any of these aspects.
Dr. Antonella Scorziello
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- neurodegenerative disorders
- neuronal death
- cellular homeostasis
- calcium homeostasis
- oxidative stress
- microglial cells
- magnetic resonance imaging
- Parkinson’s disease
- Alzheimer’s disease
- multiple sclerosis
- traumatic brain injury
- metabolic dysfunction
- diagnostic and therapeutical approaches