Neuroblastoma Molecular Biology and Therapeutics 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 August 2022) | Viewed by 2424
Special Issue Editor
2. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, 41013 Seville, Spain
Interests: cancer; metastasis; adhesion; cell migration; Rho GTPases; neuroblastoma; cellular signalling
Special Issue Information
Dear Colleagues,
As for most childhood cancers, the search of new treatments for neuroblastoma has been largely neglected by the pharmaceutical industry, even though preventive measures are not possible for the affected population. Despite improvements in the last decades, high-risk neuroblastoma is still responsible for most of the deaths of cancer patients below one year of age, and resistant aggressive relapses after treatment are still a major challenge in neuroblastoma progression. Recent collaborative efforts have put together a large collection of neuroblastoma tumor samples and developed a new deep genetic characterization to help prognosis and treatment. However, the complex biology of the disease at the cellular and molecular level is still not well understood. Known genetic drivers of the disease are scarce, and a combination of genetic, epigenetic, and developmental factors might be involved in neuroblastoma initiation and progression. Intratumor cellular heterogeneity has also emerged as an important feature in aggressive neuroblastoma progression, with the involvement of different tumor cell populations at different differentiation stages, together with stromal components. A deeper understanding of the signaling pathways and cellular interactions acting within a tumor would provide new druggable targets and therapeutic strategies to stop neuroblastoma progression and overcome resistance to the current therapies.
In this context, I would like to invite review and original articles that address the latest findings in the cellular and molecular characterization of neuroblastoma, including new therapeutic venues and molecules.
Dr. Francisco M. Vega
Guest Editor
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Keywords
- neuroblastoma biology
- cellular heterogeneity
- cellular plasticity
- signaling
- molecular targets
- differentiation
- tumor microenvironment
- drug discovery
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