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Nanomaterials for Tissue Engineering Applications 3.0

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 6825

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Special Issue Editor

Prof. Dr. Jyh-Ping Chen

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Guest Editor

Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan
Interests: drug delivery; tissue engineering; nanobiotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As nanotechnology applications in medicine have attracted worldwide interest, nanotechnological approaches to tissue engineering could also lead to many innovative solutions for repairing tissue damage. Employing three-dimensional scaffolds in tissue engineering is a key element among recent advancements in tissue engineering and biomaterial research. As scaffold materials, nanomaterials have gained popularity due to their many advantages over conventional techniques for tissue repair. Nanomaterials have shown superior performance over conventional materials for tissue engineering applications, such as in bone regeneration, cartilage repair, tendon/ligament regeneration, vascular tissue engineering, skin regeneration, nerve tissue engineering, and corneal regeneration. The ability of nanomaterials to mimic the native extracellular matrix and their ability to aid in cellular activity make these materials suitable candidates for scaffold fabrication. For instance, the high surface-to-volume ratio of nanofibers provides good cellular adhesion and rapid cell attachment on the material's surface. Interconnected pores within nanofiber membranes can facilitate nutrient and oxygen transfer. Indeed, recent nanotechnological developments have offered opportunities to greatly improve the properties of tissue-engineered scaffolds, and nanoscience approaches are suggesting some novel substitutes that could more precisely mimic the in vivo conditions of natural tissues.

This Special Issue will therefore focus on various tissue engineering approaches for the regeneration of different tissues/organs, with an emphasis on nanomaterials used in different aspects of tissue engineering and their role in tissue regeneration.

Prof. Dr. Jyh-Ping Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

tissue engineering
scaffolds
biodegradable materials
nanostructured biomaterials
regenerative medicine
bone
cartilage repair
tendon
skin

Related Special Issues

Nanomaterials for Tissue Engineering Applications in International Journal of Molecular Sciences (10 articles)
Nanomaterials for Tissue Engineering Applications 2.0 in International Journal of Molecular Sciences (2 articles)

Published Papers (3 papers)

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Research

16 pages, 4368 KiB

Open AccessArticle

Dental Composites with Magnesium Doped Zinc Oxide Nanoparticles Prevent Secondary Caries in the Alloxan-Induced Diabetic Model

by Tahreem Tanweer, Nosheen Fatima Rana, Iqra Saleem, Iqra Shafique, Sultan M. Alshahrani, Hanadi A. Almukhlifi, Amenah S. Alotaibi, Sohad Abdulkaleg Alshareef and Farid Menaa

Int. J. Mol. Sci. 2022, 23(24), 15926; https://doi.org/10.3390/ijms232415926 - 14 Dec 2022

Cited by 12 | Viewed by 1827

Abstract

Antibacterial restorative materials against caries-causing bacteria are highly preferred among high-risk patients, such as the elderly, and patients with metabolic diseases such as diabetes. This study aimed to enhance the antibacterial potential of resin composite with Magnesium-doped Zinc oxide (Mg-doped ZnO) nanoparticles (NPs) and to look for their effectiveness in the alloxan-induced diabetic model. Hexagonal Mg-doped ZnO NPs (22.3 nm diameter) were synthesized by co-precipitation method and characterized through ultraviolet-visible (UV-Vis), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analysis. The Mg-doped ZnO NPs (1, 2.5 and 5% w/w) were then evaluated for antibacterial activity using a closed system in vitro biofilm model. Significant enhancement in the antibacterial properties was observed in composites with 1% Mg-doped ZnO compared to composites with bare ZnO reinforced NPs (Streptococcus mutans, p = 0.0005; Enterococcus faecalis, p = 0.0074, Saliva microcosm, p < 0.0001; Diabetic Saliva microcosm, p < 0.0001). At 1–2.5% Mg-doped ZnO NPs concentration, compressive strength and biocompatibility of composites were not affected. The pH buffering effect was also achieved at these concentrations, hence not allowing optimal conditions for the anaerobic bacteria to grow. Furthermore, composites with Mg-doped ZnO prevented secondary caries formation in the secondary caries model of alloxan-induced diabetes. Therefore, Mg-doped ZnO NPs are highly recommended as an antibacterial agent for resin composites to avoid biofilm and subsequent secondary caries formation in high-risk patients. Full article

(This article belongs to the Special Issue Nanomaterials for Tissue Engineering Applications 3.0)

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9 pages, 971 KiB

Open AccessArticle

Estimation of SPIO Nanoparticles Uptakes by Macrophages Using Transmission Electron Microscopy

by Adham Aleid, Khalid Alhussaini, Mohammed Almijalli and Ali S. Saad

Int. J. Mol. Sci. 2022, 23(22), 13801; https://doi.org/10.3390/ijms232213801 - 09 Nov 2022

Cited by 3 | Viewed by 1364

Abstract

Due to their interesting size-dependent magnetic characteristics and relative biocompatibility, magnetic superparamagnetic iron oxide (SPIO) nanoparticles have been widely exploited as probes for cell and subcellular structure identification, as well as medication and gene delivery. A thorough understanding of the mechanics of the interaction between nanoparticles and macrophages is vital in managing dynamic processes in nanomedicine. In this study, the interaction behavior and uptake of SPIO nanoparticles by M1- and M2-type macrophages were investigated. Mice monocytes were differentiated into M1 and M2 macrophages, and the uptake of SPIO nanoparticles was studied using a TEM microscope. A high resolution image of 1 nm resolution, an image processing technique, was developed to extract the SPIO-NPs from tomographic TEM microscopic images. Lysosomes appear to be the zones of high concentrations of SPIO inside macrophages. Lysosomes were first selected in each image, and then segmentation by the Otsu thresholding method was used to extract the SPIO-NPs. The Otsu threshold method is a global thresholding technique used to automatically differentiate SPIOs from the background. The SPIO-NPs appear in red colors, and the other pixels in the image are considered background. Then, an estimation of the SPIO-NP uptakes by lysosomes is produced. Higher uptake of all-sized nanoparticles was observed in M1- and M2-type macrophages. An accurate estimation of the number of SPIO-NPs was obtained. This result will help in controlling targeted drug delivery and assessing the safety impact of the use of SPIO-NPs in nanomedicine for humans. Full article

(This article belongs to the Special Issue Nanomaterials for Tissue Engineering Applications 3.0)

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18 pages, 4121 KiB

Open AccessArticle

Photo-Crosslinked Hyaluronic Acid/Carboxymethyl Cellulose Composite Hydrogel as a Dural Substitute to Prevent Post-Surgical Adhesion

by Yin-Cheng Huang, Zhuo-Hao Liu, Chang-Yi Kuo and Jyh-Ping Chen

Int. J. Mol. Sci. 2022, 23(11), 6177; https://doi.org/10.3390/ijms23116177 - 31 May 2022

Cited by 16 | Viewed by 3176

Abstract

A dural substitute is frequently used to repair dura mater during neurosurgical procedures. Although autologous or commercially available dural substitutes matched most of the requirements; difficulties during dural repair, including insufficient space for suturing, insufficient mechanical strength, easy tear and cerebrospinal fluid leakage, represent major challenges. To meet this need, a photo-crosslinked hydrogel was developed as a dural substitute/anti-adhesion barrier in this study, which can show sol-to-gel phase transition in situ upon short-time exposure to visible light. For this purpose, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), materials used in abdominal surgery for anti-adhesion purposes, were reacted separately with glycidyl methacrylate to form hyaluronic acid methacrylate (HAMA) and carboxymethyl cellulose methacrylate (CMCMA). The HA/CMC (HC) hydrogels with different HA compositions could be prepared by photo-crosslinking HAMA and CMCMA with a 400 nm light source using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photo-initiator. From studies of physico-chemical and biological properties of HC composite hydrogels, they are bio-compatible, bio-degradable and mechanically robust, to be suitable as a dural substitute. By drastically reducing attachment and penetration of adhesion-forming fibroblasts in vitro, the HC hydrogel can also act as an anti-adhesion barrier to prevent adhesion formation after dural repair. From in vivo study in rabbits, the HC hydrogel can repair dural defects as well as protect the dura from post-operative adhesion, endorsing the possible application of this hydrogel as a novel dural substitute. Full article

(This article belongs to the Special Issue Nanomaterials for Tissue Engineering Applications 3.0)

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