Multiple Myeloma and Chronic Lymphocytic Leukemia: From Molecular Biology to Immunology to Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5842
Special Issue Editors
Interests: multiple myeloma; tumor immunology; T cell response; immunotherapy; chronic lymphocytic leukemia; monoclonal gammopaty; amyloidosis; CAR-T
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) are both B-cell malignancies, which arise from the clonal expansion of progenitor cells at different stages of B-cell maturity. Clinically, MM and CLL share common features, such as stage‐dependent anaemia, immune deficiency, and late stage unresponsiveness to therapy; indeed, despite the recent introduction of new drugs, both are still incurable. Additionally, both diseases are considered microenvironment-dependent malignancies, in which neoplastic B cells co-evolve together with a supportive tissue microenvironment, leading to chronic inflammation and severe impairment of immune effectors. Specific genomic alterations, such as del17p, identify high-risk patients, which could benefit from specific treatments, while other molecular markers are currently under evaluation.
This Special Issue “Multiple Myeloma and Chronic Lymphocytic Leukemia: from molecular biology to immunology to therapy” of the International Journal of Molecular Sciences, has the objective to develop an updated biological and clinical view on how molecular and immunological alterations impact pathogenesis, disease evolution from asymptomatic early stage disease, therapeutic response and clinical outcome. We welcome original basic, translational and molecular biology-based clinical research articles as well as review articles leading to improvement of the understanding of both MM and CLL disease.
Dr. Cirino Botta
Dr. Massimo Gentile
Guest Editors
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Keywords
- multiple myeloma
- chronic lymphocytic leukemia
- P53
- translational medicine
- personalized treatment
- target therapy
- immuno-oncology
- biomarkers
- genetic alteration
- diagnostics and therapeutics
- molecular biology
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