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Review

Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia

Central European Institute of Technology (CEITEC), Masaryk University, 62500 Brno, Czech Republic
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Authors to whom correspondence should be addressed.
Academic Editor: Cirino Botta
Int. J. Mol. Sci. 2021, 22(11), 5536; https://doi.org/10.3390/ijms22115536
Received: 13 April 2021 / Revised: 16 May 2021 / Accepted: 19 May 2021 / Published: 24 May 2021
Chimeric antigen receptor (CAR) T-cell therapy has already achieved remarkable remissions in some difficult-to-treat patients with B-cell malignancies. Although the clinical experience in chronic lymphocytic leukemia (CLL) patients is limited, the proportion of remissions reached in this disease is clearly the lowest from the spectrum of B-cell tumors. In this review, we discuss the antigenic targets exploited in CLL CAR-T therapy, the determinants of favorable responses, as well as the mechanisms of treatment failure specific to this disease. View Full-Text
Keywords: chimeric antigen receptor; immunotherapy; chronic lymphocytic leukemia; CD19 chimeric antigen receptor; immunotherapy; chronic lymphocytic leukemia; CD19
MDPI and ACS Style

Mancikova, V.; Smida, M. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. Int. J. Mol. Sci. 2021, 22, 5536. https://doi.org/10.3390/ijms22115536

AMA Style

Mancikova V, Smida M. Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia. International Journal of Molecular Sciences. 2021; 22(11):5536. https://doi.org/10.3390/ijms22115536

Chicago/Turabian Style

Mancikova, Veronika, and Michal Smida. 2021. "Current State of CAR T-Cell Therapy in Chronic Lymphocytic Leukemia" International Journal of Molecular Sciences 22, no. 11: 5536. https://doi.org/10.3390/ijms22115536

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