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Special Issue "Molecular Research on Mucosal Immunity"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2018).
Institute for Infection and Immunity, Novel Therapeutics and Vaccinology Centre, St George’s, University of London, Cranmer Terrace, London SW17 0RE, UK
Interests: molecular basis of allergenicity; Innate immune signalling; drug design and development; asthma; atopic dermatitis; allergic rhinitis
We invite you to submit reviews, commentaries or research papers for this Special Issue “Molecular Research on Mucosal Immunity”, which will focus on recent advances and future priorities in this field. We welcome articles with a cellular or molecular mechanistic focus, those with clinical orientation, or those offering cross-functional perspectives that will inspire others to engage with this research community.
Innate and adaptive mechanisms protect mucosal surfaces (e.g., the skin, gastrointestinal tract, genitourinary tract and respiratory tract) against potential pathogens and also guard against inappropriate responses to innocuous proteins, such as food components and allergens. However, abnormal operation of these processes causes disease. The past 40 years have seen an explosion in our understanding of cellular and molecular events following the cross-linkage of allergen-specific IgE on mast cells and basophils. In contrast, less attention has been given to understanding events which lie upstream, such as the nature of allergenicity and the initiation of allergic sensitisation. Recent progress on these questions, and how they are affected by other mucosal responses such as antiviral defence, make it timely to review the field and next steps. Therefore, this Special Issue will focus on recent advances in understanding the relationship between innate immune responses and the development of allergic disease. It will examine recent progress in understanding the molecular basis of allergenicity and how allergens initiate and/or exacerbate disease mechanisms at mucosal surfaces through elaborate innate signalling events which are now being revealed as central to mucosal responses to a miscellany of unrelated pathogenetic agents.
Prof. Dr. Clive Robinson
Prof. Dr. Geoffrey Stewart
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- atopic dermatitis
- allergic rhinitis
- food allergy
- antigen presentation
- allergen structure and function
- innate lymphoid cells
- pattern recognition receptors and their ligands
- allergen-virus interactions
- inflammatory mediators
- intercellular junctions