Microglia Heterogeneity and Its Relevance for Translational Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 48529
Special Issue Editors
Interests: neuroinflammation; glial cells; myeloid cells; microglia; brain tumours; immuno-oncology; neurodegeneration; immunometabolism
Interests: microglia; myeloid cells; neuroinflammation; neurodegeneration; neuropsychiatry; regenerative medicine; stem cells
Interests: microglia; myeloid cells; neuroinflammation; remyelination; myelination; regenerative medicine; stem cells; oligodendrocyte
Special Issue Information
Dear Colleagues,
Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the singular environment of the central nervous system (CNS), make microglia a rather unique population of immune effector cells. The exceptional properties of microglial cells during development, as well as in the adult CNS, such as their role in synaptic stripping or the remarkable capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in the past. More recently, technological advances in molecular biology, imaging, and single-cell analyses have further provided fascinating insights into the dynamic changes and diversity of microglia in response to aging and brain diseases, revealing their potential as therapeutic targets.
This Special Issue aims to provide a comprehensive overview of our current understanding of the diversity of microglia spanning from brain regional heterogeneity under homeostasis to disease-associated microglia emerging with distinct transcriptional profiles reflecting specific activation states under pathological settings, including tumorigenic and degenerative processes. Thus, we welcome the submission of articles that cover, but are not limited to the role of microglia in inflammatory processes associated with brain diseases as well as strategies for patient stratification, diagnostics or treatment of CNS disorders based on dynamic molecular changes in microglia.
Dr. Alessandro Michelucci
Prof. Dr. Josef Priller
Dr. Veronique Miron
Guest Editors
Manuscript Submission Information
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Keywords
- Microglia
- Heterogeneity
- Neuroinflammation
- Neurodegeneration
- Brain tumours
- Translational medicine
- Immunotherapy
- Precision medicine
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