Special Issue "Pathophysiology of Liver Fibrosis and Its Therapies"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2020).
Interests: alpha1-antitrypsin; hemochromatosis; non-invasive markers; animal models; keratins
Special Issues and Collections in MDPI journals
Liver fibrosis is a conserved response to chronic hepatocellular stress that results in cell death and activation of multiple signalling pathways. It is characterized by the activation of stellate cells and progressive deposition of the extracellular matrix. Alcoholic and non-alcoholic liver disease are the leading causes of liver fibrosis in the Western world, with lipotoxicity, an alteration of the gut–liver axis, and the resulting inflammation being among the well-known disease pathomechanisms. A better understanding of the transition process from a healthy liver to end-stage disease is needed to enable the prediction of individual disease courses. In advanced fibrosis, the development of portal hypertension and its associated complications are determinants of the patient´s prognosis, but these processes are still incompletely understood. This upcoming Special Issue of IJMS aims to reflect the diversity of this complex process and bring together biologists, immunologists, and bioinformaticians to highlight the progress in the field.
We invite authors to submit original research and review articles regarding the molecular/cellular aspects of liver fibrosis including, but not limited to, the following topics:
- Hepatic stellate cells;
- Non-alcoholic fatty liver disease;
- Gut–liver axis;
- Cell death;
- Alcohol-related liver injury;
- Phase transition;
- Portal hypertension;
- Liver cirrhosis.
Dr. Pavel Strnad
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- hepatic stellate cell;
- non-alcoholic fatty liver disease;
- gut–liver axis;
- cell death;
- alcohol-related liver injury;
- phase transition;
- portal hypertension;
- liver cirrhosis.