Leptin and Relatives: Molecules at the Crossroad of Inflammation and Immunometabolism

Dear Colleagues,

Next year, in 2019, we will celebrate the 25^th anniversary of the discovery of leptin, the first member of the novel, recognized superfamily of molecules, collectively named adipokines. A quarter of a century, characterized by a plethora of studies that have led to the appreciation of the remarkable potency, range of biological effects and pleiotropism of leptin, as well as of many other adipokines. Leptin research in the last 25 years has significantly increased our understanding of the cellular and molecular mechanisms linking obesity and adipose tissue dysfunction to metabolic/immune/inflammatory disorders, a picture that is still incomplete. Research on leptin and relatives has permeated almost all biomedical disciplines, from endocrinology to rheumatology, just to simply cite a few. We invite authors to present original research articles, as well as review articles, that will stimulate the continue efforts in defining the molecular and cellular mechanisms of leptin and other adipokines in pathophysiology and clinics. Papers describing compelling mechanistic evidence linking the effects of leptin, and other adipokines, to the pathogenesis of immune–inflammatory–metabolic diseases are very welcome. Manuscripts reporting clinical applications of approved or investigational-adipokines research-based drugs with an emphasis on the cellular and molecular effects related to the efficacy, toxicity, response assessment, multimodality treatment, prognostic factors and predictive markers are also very welcome.

Dr. Oreste Gualillo
Guest Editor

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