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Leptin and Immunological Profile in Obesity and Its Associated Diseases in Dogs

1,*,†, 2,3,*,† and 4,5,*,†
Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy
Department of Science, University of Basilicata, 85100 Potenza, Italy
Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy
Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Institute of Biostructures and Bioimages (IBB), National Research Council (CNR), 80131 Naples, Italy
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(10), 2392;
Received: 1 April 2019 / Revised: 6 May 2019 / Accepted: 8 May 2019 / Published: 14 May 2019
PDF [1369 KB, uploaded 14 May 2019]


Growing scientific evidence has unveiled increased incidences of obesity in domestic animals and its influence on a plethora of associated disorders. Leptin, an adipokine regulating body fat mass, represents a key molecule in obesity, able to modulate immune responses and foster chronic inflammatory response in peripheral tissues. High levels of cytokines and inflammatory markers suggest an association between inflammatory state and obesity in dogs, highlighting the parallelism with humans. Canine obesity is a relevant disease always accompanied with several health conditions such as inflammation, immune-dysregulation, insulin resistance, pancreatitis, orthopaedic disorders, cardiovascular disease, and neoplasia. However, leptin involvement in many disease processes in veterinary medicine is poorly understood. Moreover, hyperleptinemia as well as leptin resistance occur with cardiac dysfunction as a consequence of altered cardiac mitochondrial metabolism in obese dogs. Similarly, leptin dysregulation seems to be involved in the pancreatitis pathophysiology. This review aims to examine literature concerning leptin and immunological status in obese dogs, in particular for the aspects related to obesity-associated diseases. View Full-Text
Keywords: leptin; dog; obesity; immune function; physiology; human leptin; dog; obesity; immune function; physiology; human

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Cortese, L.; Terrazzano, G.; Pelagalli, A. Leptin and Immunological Profile in Obesity and Its Associated Diseases in Dogs. Int. J. Mol. Sci. 2019, 20, 2392.

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