Insulin Pathways for Therapeutic Intervention

Dear Colleagues,

Pleiotropy of insulin and its related peptides (ILPs), particularly IGFs, makes ILP pathways of great therapeutic potential, as an ever increasing number of pathologies are being recognized to involve deficient ILP activity. On top of the classical endocrine-related maladies, where the role of ILPs is well established, such as metabolic and growth disorders associated in turn to cardiovascular, bone, and renal disturbances, compelling evidence indicates that ILPs are involved in brain diseases, circadian disruption, and even tumor pathology. Together with the relatively recent advent of geroscience as a target of medical intervention, and given the prominent role of ILPs in normal and pathological aging, we may consider that pathways involved in ILP signaling constitute a major source of druggable targets as they encompass all the main types of human diseases. A better understanding of inter- and intracellular ILP communication as well as their molecular mediators is therefore of paramount medical importance.

Prof. Dr. Ignacio Torres Aleman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.