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Special Issue "Insulin Pathways for Therapeutic Intervention"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editor

Prof. Dr. Ignacio Torres Aleman
E-Mail Website
Guest Editor
Systems Neurobiology, Cajal Institute (CSIC), Madrid, Spain
Interests: neurobiology of insulin peptides; blood–brain barrier; neurodegeneration; energy homeostasis; regulation of mood and cognition
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Pleiotropy of insulin and its related peptides (ILPs), particularly IGFs, makes ILP pathways of great therapeutic potential, as an ever increasing number of pathologies are being recognized to involve deficient ILP activity. On top of the classical endocrine-related maladies, where the role of ILPs is well established, such as metabolic and growth disorders associated in turn to cardiovascular, bone, and renal disturbances, compelling evidence indicates that ILPs are involved in brain diseases, circadian disruption, and even tumor pathology. Together with the relatively recent advent of geroscience as a target of medical intervention, and given the prominent role of ILPs in normal and pathological aging, we may consider that pathways involved in ILP signaling constitute a major source of druggable targets as they encompass all the main types of human diseases. A better understanding of inter- and intracellular ILP communication as well as their molecular mediators is therefore of paramount medical importance.

Prof. Dr. Ignacio Torres Aleman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insulin
  • insulin-like peptides
  • human diseases
  • therapy
  • drug targets
  • signaling pathways

Published Papers (1 paper)

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Review

Open AccessReview
Insulin Receptor Trafficking: Consequences for Insulin Sensitivity and Diabetes
Int. J. Mol. Sci. 2019, 20(20), 5007; https://doi.org/10.3390/ijms20205007 - 10 Oct 2019
Abstract
Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the pathology of metabolic disorders including type 2 diabetes mellitus (T2DM). The mainstream opinion is that [...] Read more.
Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the pathology of metabolic disorders including type 2 diabetes mellitus (T2DM). The mainstream opinion is that insulin resistance begins at a post-receptor level. The role of INSR activities and trafficking in insulin resistance pathogenesis has been largely ignored. Ligand-activated INSR is internalized and trafficked to early endosome (EE), where INSR is dephosphorylated and sorted. INSR can be subsequently conducted to lysosome for degradation or recycled back to the plasma membrane. The metabolic fate of INSR in cellular events implies the profound influence of INSR on insulin signaling pathways. Disruption of INSR-coupled activities has been identified in a wide range of insulin resistance-related diseases such as T2DM. Accumulating evidence suggests that alterations in INSR trafficking may lead to severe insulin resistance. However, there is very little understanding of how altered INSR activities undermine complex signaling pathways to the development of insulin resistance and T2DM. Here, we focus this review on summarizing previous findings on the molecular pathways of INSR trafficking in normal and diseased states. Through this review, we provide insights into the mechanistic role of INSR intracellular processes and activities in the development of insulin resistance and diabetes. Full article
(This article belongs to the Special Issue Insulin Pathways for Therapeutic Intervention)
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