Cell Lineage Choice during Haematopoiesis 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 7538
Special Issue Editor
Interests: the use of synthetic retinoids and vitamins D as drug substances; cancer and normal stem cells; anticancer therapies; blood cell development; abnormalities in cancer stem cells
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Special Issue Information
Dear Colleagues,
This Special Issue is the second volume of our previous Special Issue “Cell Lineage Choice during Hematopoiesis: A Commemorative Issue in Honor of Professor Antonius Rolink”.
For more than 30 years, we seemed to have a very clear picture of how the hematopoietic stem cell (HSC) gives rise to the many different types of blood and immune cells. In the classic lineage tree model, HSC follows a prescribed route to each of the end cell types and gradually restricts their alternative choices via a series of intermediate oligo-potent progenitor cells. Recent findings have challenged these principles, leading to a very different viewpoint whereby a continuum of each fate option is open to HSCs. Thus, HSCs have lineage biases/affiliations and progenitor cells in bone marrow are either pluripotent or unipotent. Thus, HSCs can make an immediate choice without traversing a series of intermediate progenitors to progressively close down developmental options. Developing cells can move sideways to adopt an alternative fate. This Special Issue will examine the shift toward a new architecture for the blood cell system and how the development of such cells is controlled.
Dr. Geoffrey Brown
Guest Editor
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Keywords
- The haematopietic stem cell
- The nature of haematopoietic progenitors
- Decision-making during haematopoiesis
- Modelling haematopoiesis
- Culture and in vivo model systems for studying haematopoiesis
- T lymphocyte development
- B lymphocyte decelopment
- The diversity of the mature types of blood cells
- Molecular controls on haematopoiesis
- Haematopoietic growth factors
- Differentiating agents
- Implications of our understanding of haematopoiesis to leukaemia
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