Special Issue "Glycosylation-Based Biomarkers in Diseases and Drug Delivery"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2020.
Interests: Protein glycosylation; biomarkers; glyco(proteo)mics; extracellular vesicles; glycosyltransferases; amyotrophic lateral sclerosis; cerebrospinal fluid; neurodegeneration; cancer
Interests: Protein glycosylation; glycans; glycoproteomics; glycobiomarkers; glycoimmunology; oncobiology; Inflammation
Glycoconjugates, such as, glycoproteins, proteoglycans and glycolipids, are major components of cells and organisms. A high diversity of glycan structures are present in different cellular types, being involved in major cellular and molecular processes both in homeostasis and in diseases. Therefore, specific glycosignatures displayed by cells, tissues or biofluids constitute valuable biomarkers of disease with important clinical applications. In the field of cancer changes in glycosylation have long been recognized and, consequently, several glycan-based biomarkers have been identified. For other diseases, such as inflammation and neurological diseases, the potential of glycosylation as biomarker is also relevant.
Glycans mediate cell recognition events (e.g., by immune cells) through their interaction with lectins and receptors, which provide potential tools for drug delivery onto specific target cells, acting also as promising vaccines. In this context, glycosyltransferases and glycosidases, enzymes that participate in the biosynthesis of glycans in vivo, constitute useful tools for glycosylation remodeling.
This Special issue will include papers addressing glycoconjugates/glycosylation as relevant disease biomarkers that can aid in diagnosis and prognosis. The role of glycans in the understanding of disease ethiopathogenesis and as promising targets for new therapies in context of precision medicine are considered. Furthermore, studies on glycosylation for the improvement of targeted drug delivery are welcome.
Dr. Júlia Costa
Prof. Salomé S. Pinho
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Glycan-based biomarkers for disease (particularly, cancer, neurodegeneration, chronic inflammatory diseases, neurological disorders, inflammation, autoimmunity, congenital disorders of glycosylation).
- Glycans in the immune system.
- Glyco(proteo)mics strategies for novel biomarker identification.
- Glycosylation and metabolomics in disease.
- Glycoconjugates/glycosylation from extracellular vesicles as biomarkers and implications in delivery.
- Glycoengineering of nanoparticle surfaces aiming at improved delivery.
- Lectins and glycan receptors in recognition mechanisms and diagnosis.