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Special Issue "Microgravity and Cell Adherence"
Deadline for manuscript submissions: 31 December 2019.
Interests: cell adhesion; organoid formation
Cell adherence is changed when cells are exposed to microgravity. This is true for human and animal tissue cells, as well as for microorganisms exposed to simulated or real microgravity. In human or animal cells, changes of adherence became especially apparent when scaffold-free organoid formation was investigated, which included the cells’ detachment from the surface of the culture flasks, followed by three-dimensional aggregation. In this process, distinct proteins and genes coding for them have already been identified, which contribute either to a cell’s adherence to a substratum or to contact with neighboring cells. Furthermore, adhesion-dependent initiation of microbial biofilm formation can be triggered by microgravity-induced changes of gene expression patterns, protein accumulation, and carbohydrate metabolism.
In both cases, the kind and force of adherence are regulated by external and internal signals. External signals are exerted by features of the surface to which the cells adhere. Internal signals have been described repeatedly. However, their generation by the influence of microgravity requires further investigation.
Articles and reviews will be collected in which either the chemical/biochemical background of external signals is described, or cellular mechanisms are unveiled that up- or down-regulate the cells’ adhesion to their environment under microgravity.
Dr. Johann Bauer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Cell monolayer
- Organoid formation
- Adhesion proteins
- Tight junction