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Microbiomes in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 660

Special Issue Editor

Special Issue Information

Dear Colleagues,

Over recent decades microbiome research has undergone rapid growth, especially due to the development and availability of cost-effective next-generation sequencing techniques. Fascinating insights into the influence of microbial communities on human health have already been made. Nevertheless, our understanding of the various and complex interactions of microbes and humans is still limited. Therefore, it is the dedicated aim of this Special Issue to expand our knowledge on this fascinating field of research and to collect the latest studies on human microbiomes. Research articles, short communications, and reviews dealing with the question of how these microbiomes impact development, health, and disease, as well as studies on the development and application of new tools and approaches to study microbiomes in human health and disease, are welcome.

Prof. Dr. Andreas Burkovski
Guest Editor

Manuscript Submission Information

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Keywords

  • microbiome
  • dysbiosis
  • commensal bacteria
  • pathobiont
  • metabolites
  • immune modulation
  • nutrient metabolism
  • barrier function
  • health and disease

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Published Papers (1 paper)

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Review

20 pages, 1277 KB  
Review
The Urinary Microbiota and the Gut–Bladder Axis in Bladder Cancer
by Usman Akhtar Butt and Daniela De Biase
Int. J. Mol. Sci. 2025, 26(21), 10558; https://doi.org/10.3390/ijms262110558 - 30 Oct 2025
Abstract
The human bladder hosts a resident, low-biomass microbial community (urobiota) that has only become the subject of intense investigation in the last 15 years. The advantages that the urobiota may confer to the bladder, in contrast to the microbiota of other mucosal sites, [...] Read more.
The human bladder hosts a resident, low-biomass microbial community (urobiota) that has only become the subject of intense investigation in the last 15 years. The advantages that the urobiota may confer to the bladder, in contrast to the microbiota of other mucosal sites, remain to be elucidated. Alterations in the urobiota have been associated with various pathological urogenital conditions, including urinary tract infections (UTIs) and recurrent UTIs. A potential link between bladder cancer (BC), the ninth most common human cancer by incidence worldwide, and a dysbiotic urobiota is still unclear and represents an emerging field of study. In this review, we focus on recent studies that not only analyzed the urobiota of BC patients using urine specimens to identify biomarkers and microbial signatures of the disease, but also monitored therapeutic responses to therapies. We also discuss novel techniques of culturing, such as culturomics, animal models of BC, and 3D organotypic models. Furthermore, we review studies on the gut–bladder axis which, though still limited, already suggest that diet- and gut-derived bacterial metabolites can influence BC progression and individual responses to therapy. Full article
(This article belongs to the Special Issue Microbiomes in Human Health and Disease)
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