Molecular Research of Autophagy and Apoptosis 2022
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 1673
Special Issue Editor
Interests: cell death; cell survival; autophagy; apoptosis; phagocytosis; inflammation; model organisms; lysosome; tumor metabolism; therapy resistance
Special Issue Information
Dear Colleagues,
Balance between cell death and survival is of key importance in maintaining cellular homeostasis. Three major types of programmed cell death (PCD) have been distinguished: apoptosis (type I), autophagic cell death (type II), and necrosis (type III), which are interconnected through molecular crosstalk mechanisms. In addition to human studies, research on model organisms contributed significantly to identification of conserved molecular pathways constituting different types of PCD. Characterization of the complex interplay among PCD processes is crucial as it underlies the pathogenesis of multiple diseases, especially cancer.
Recent studies show that apoptosis is a barrier that tumor cells have to overcome in order to survive. Elimination of apoptotic cell debris by phagocytosis is required to prevent inflammation, which is known as a factor that might favour tumor progression. Autophagy, which was originally characterized as a cell survival mechanism in response to starvation but also known as a cell death modulator, may influence the pathological conditions of cancer by altering metabolic conditions.
Further elucidation of basic molecular mechanisms playing a role in PCD processes, furthermore better understanding of their interactions may pave the way for new treatment strategies of cancer.
Dr. Krisztina Takács-Vellai
Guest Editor
Manuscript Submission Information
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Keywords
- cell death
- cell survival
- autophagy
- apoptosis
- phagocytosis
- inflammation
- model organisms
- lysosome
- tumor metabolism
- therapy resistance
