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Special Issue "Molecular Control of Adipose Cell Fate and Energy Metabolism"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editor

Guest Editor
Dr. Takeshi Yoneshiro

Department of Cell and Tissue Biology, University of California, San Francisco.
Website | E-Mail
Interests: obesity; diabetes; brown adipose tissue; metabolic disease; thermogenesis; beige adipocytes; mitochondrial homeostasis

Special Issue Information

Dear Colleagues,

Adipose tissues play a central role in energy homeostasis. Metabolic phenotypes of brown (BAT) and white adipose tissues (WAT) vary substantially in response to environmental cues. For instance, cold exposure is the physiological cue for stimulating adipose metabolic thermogenesis and results in BAT hyperplasia and browning of WAT via sympathetic nervous activation in small rodents. These manifestations in adipose thermogenesis not only facilitate the maintenance of body temperature in the cold but also result in the significant reduction of body fat content, improving insulin resistance. The rediscovery of metabolically active BAT in healthy adult humans in 2009 has given impetus to research on human BAT as a potential target to fight obesity and related metabolic diseases such as type 2 diabetes. However, despite several recent studies demonstrating that cold acclimation indeed recruits BAT in healthy humans, the BAT-targeting regimen remains a challenge for researchers and clinicians because chronic cold exposure in daily life is difficult to achieve for obese or diabetic patients owing to its uncomfortability and potential negative effects on cardiovascular function. The investigation and identification of molecular circuits that regulate the fate specification of brown adipocytes or brown-like (beige) adipocytes may lead to an alternative and effective therapeutic intervention targeting adipose tissue thermogenesis to counteract human obesity and metabolic disorders. To this end, more insights are needed into the physiological significance of human BAT and mechanisms by which BAT function is regulated by aging, as well as endogenous and environmental factors.

Thus, here we would like to highlight the current understand of molecular circuits that determine the fate specification of brown adipose cells and to investigate their physiological roles in energy homeostasis both in experimental animals and in humans. We also would like to depict advances in adipose tissue homeostasis and its metabolic implications for inflammation, obesity, as well as links to metabolic diseases.

Dr. Takeshi Yoneshiro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Brown adipose tissue
  • Beige adipose tissue
  • Energy homeostasis
  • Molecular circuits
  • Inflammation
  • Obesity
  • Metabolic diseases

Published Papers (2 papers)

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Research

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Open AccessArticle
Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans
Int. J. Mol. Sci. 2019, 20(9), 2214; https://doi.org/10.3390/ijms20092214
Received: 9 April 2019 / Revised: 26 April 2019 / Accepted: 4 May 2019 / Published: 6 May 2019
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Abstract
Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup [...] Read more.
Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup, oxygenated Hb [oxy-Hb]sup, deoxygenated Hb [deoxy-Hb]sup, Hb O2 saturation (StO2sup), and the reduced scattering coefficient in the supraclavicular region (μssup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb]sup and [oxy-Hb]sup show region-specific increases in winter, compared to summer. Further, [total-Hb]sup and [oxy-Hb]sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb]sup and [oxy-Hb]sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner. Full article
(This article belongs to the Special Issue Molecular Control of Adipose Cell Fate and Energy Metabolism)
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Review

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Open AccessReview
Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity
Int. J. Mol. Sci. 2019, 20(11), 2768; https://doi.org/10.3390/ijms20112768
Received: 3 May 2019 / Revised: 29 May 2019 / Accepted: 31 May 2019 / Published: 5 June 2019
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Abstract
Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the most abundant ions in the human [...] Read more.
Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the most abundant ions in the human body. A large number of studies have shown that calcium signaling could play a major role in increasing energy consumption by enhancing the metabolism and the differentiation of adipocytes and reducing food intake through regulating neuronal excitability, thereby effectively decreasing the occurrence of obesity. In this paper, we review multiple calcium signaling pathways, including the IP3 (inositol 1,4,5-trisphosphate)-Ca2+ (calcium ion) pathway, the p38-MAPK (mitogen-activated protein kinase) pathway, and the calmodulin binding pathway, which are involved in biological clock, intestinal microbial activity, and nerve excitability to regulate food intake, metabolism, and differentiation of adipocytes in mammals, resulting in the improvement of obesity. Full article
(This article belongs to the Special Issue Molecular Control of Adipose Cell Fate and Energy Metabolism)
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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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