Next Article in Journal
Cardio-Metabolic Disorders in Non-Alcoholic Fatty Liver Disease
Next Article in Special Issue
Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity
Previous Article in Journal
Medical Treatment for Osteoporosis: From Molecular to Clinical Opinions
Article Menu
Issue 9 (May-1) cover image

Export Article

Open AccessArticle

Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans

1
Division of Preventive Medicine, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Kyoto 612-8555, Japan
2
Department of Sports Medicine for Health Promotion, Tokyo Medical University, Tokyo 160-8402, Japan
3
Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo 160-8402, Japan
4
Faculty of Sports and Health Science, Daito Bunka University, Higashimatsuyama-shi, Saitama 355-8501, Japan
5
Department of Nutrition, Tenshi College, Sapporo 065-0013, Japan
6
Hokkaido University, Sapporo 060-0818, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(9), 2214; https://doi.org/10.3390/ijms20092214
Received: 9 April 2019 / Revised: 26 April 2019 / Accepted: 4 May 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Molecular Control of Adipose Cell Fate and Energy Metabolism)
  |  
PDF [560 KB, uploaded 6 May 2019]
  |     |  

Abstract

Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup, oxygenated Hb [oxy-Hb]sup, deoxygenated Hb [deoxy-Hb]sup, Hb O2 saturation (StO2sup), and the reduced scattering coefficient in the supraclavicular region (μssup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb]sup and [oxy-Hb]sup show region-specific increases in winter, compared to summer. Further, [total-Hb]sup and [oxy-Hb]sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb]sup and [oxy-Hb]sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner. View Full-Text
Keywords: 18F-fluorodeoxyglucose-positron emission tomography; noninvasive; brown adipose tissue (BAT); seasonal temperature fluctuations; cold-induced thermogenesis; thermogenic functional ingredients 18F-fluorodeoxyglucose-positron emission tomography; noninvasive; brown adipose tissue (BAT); seasonal temperature fluctuations; cold-induced thermogenesis; thermogenic functional ingredients
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Nirengi, S.; Fuse, S.; Amagasa, S.; Homma, T.; Kime, R.; Kuroiwa, M.; Endo, T.; Sakane, N.; Matsushita, M.; Saito, M.; Kurosawa, Y.; Hamaoka, T. Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans. Int. J. Mol. Sci. 2019, 20, 2214.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top