Insulinoma: From Molecular Mechanisms to Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2236
Special Issue Editors
Interests: clinical endocrinology; endocrine pathology; neuroendocrine tumours; thyroid disorders
Interests: endocrine pathology; gastrointestinal pathology; liver pathology; neuroendocrine tumours; thyroid disorders; tumour biomarkers; digital pathology
Special Issue Information
Dear Colleagues,
Insulinomas are rare neuroendocrine neoplasms (NEN) of the pancreas, with an incidence of 1−4 million/year. Although insulinomas are usually benign, they may result in life-threatening hypoglycaemia, and approximately 10% of the tumours present with metastases and a poor prognosis. The diagnostics, localization, and treatment of insulinomas are challenging in many aspects, but recent and ongoing advances, for example, in the fields of molecular pathology and functional imaging, provide us with better tools to tackle these challenges.
The scope of this Special Issue is to draw together relevant basic, translational, and clinical research on insulinomas. Authors are invited to submit original and review articles, addressing the progress and state of the art in insulinoma research.
Topics of this Special Issue on insulinomas include, but are not limited to:
- Epidemiology and risk factors;
- Key biological processes such as angiogenesis, invasion and metastasis, and signalling;
- Molecular pathology;
- Biomarkers for the diagnosis, prognosis, and treatment response of insulinomas;
- Genomics, proteomics, and other omics: findings and applications;
- Treatment: surgery, pharmacotherapy, molecular targeted therapies, etc.
Dr. Pia Jaatinen
Prof. Dr. Johanna Arola
Guest Editors
Manuscript Submission Information
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Keywords
- insulinoma
- neuroendocrine neoplasm
- molecular pathology
- biomarkers
- treatment
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