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Prebiotics and Probiotics: Healthy Biotools for Molecular Integrative and Modulation Approaches—3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 95

Special Issue Editors

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Guest Editor
1. Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18011 Granada, Spain
2. Instituto de Investigación Biosanitaria (IBS), 18014 Granada, Spain
3. Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. Armilla, 18016 Granada, Spain
Interests: nutrition and dietetics nutritional; biochemistry; pharmacy; cell biology; molecular biology; immunology; regulation of the gene expression in prokaryotes and eukaryotes; pathogens; enzymology and biotechnology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Microbiology, Faculty of Pharmacy, University of Granada, 18011 Granada, Spain
2. Instituto de Investigación Biosanitaria (IBS), 18014 Granada, Spain
3. Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. Armilla, 18016 Granada, Spain
Interests: probiotics; next-generation probiotics; molecular microbiology; microbiome; culturomics and toxicomicrobiomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the continuation of our Special Issues https://www.mdpi.com/journal/ijms/special_issues/_Prebiotics_Probiotic and https://www.mdpi.com/journal/ijms/special_issues/4NK7379EDM.

The key role played by beneficial bacteria in the intestines by promoting overall human health is generally accepted. Helpful bacteria in the colon have many important functions that include increasing mineral homeostasis, strengthening the intestinal barrier, regulating the immune response and therefore human health and wellbeing. Hence, probiotics and prebiotics are food bioproducts that exert key functions in maintaining human gut eubiosis, and are specially designed for this purpose.

After decades of basic and clinical research, together with the evolution of biotechnological and high-throughput technologies, a huge impact on understanding the effect of probiotics, prebiotics on the immune response and antibacterial infection has been achieved. Thus, these biotools have become the main instruments to intervene in and optimize several physiological functions of the microbiota. Moreover, considerable efforts have been made to influence the intestinal microbiota by dietary complementary means in such a way that the health of the host is positively affected.

Functional foods are those which provide benefits beyond their traditional nutritional value, either enhancing a function of the body or reducing the risk of a disease. Among the main types of functional foods are prebiotics, which are non-digestible foods (mostly oligosaccharides) that selectively stimulate the growth of a limited number of host-friendly colonic bacteria. From a chemical standpoint, resistance to human digestive enzymes and low absorption are the key for these compounds to reach the distal parts of the gut where they can be fermented by the microbiota, which in turn is selectively modified in the process. It is important to note that pathological alterations of the intestinal microbiota (dysbiosis) have been related to conditions such as obesity, diabetes and fatty liver, as well as inflammatory bowel disease and infection with pathogenic bacteria.

It is clear that the diversity of prebiotic substances and probiotic microbes, and the influences that they may, respectively, exert mean that any health enhancement claims must be supported by experimental and clinical data. However, the molecular mechanisms and interactions of prebiotics and probiotics with their specific targets for immune responses are not well known, and such information will help identify new alternative compounds as therapies against various pathologies.

The goal of this Special Issue is to further expand our knowledge of the molecular mechanism of prebiotics and probiotics, as well as offer a complete and broad view of the current situation in the area and its future projection, pointing out the new indications that will enrich this field.

For this Special Issue, we welcome innovative and original research articles, as well as high-quality review articles outlining pioneering opinions with a focus on probiotics and prebiotics and host health/disease balance, related to their antibacterial roles.

Prof. Dr. Abdelali Daddaoua
Prof. Dr. Margarita Aguilera
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • prebiotics
  • probiotics
  • molecular microbiology
  • immunology
  • microbiome

Published Papers

This special issue is now open for submission.
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