Epigenetics in Neurodegenerative Diseases: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 November 2025
Special Issue Editors
Interests: human viruses; immunity; antibody; Alzheimer’s disease; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Interests: human viruses; immunity; humoral response; Alzheimer’s disease; multiple sclerosis; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is a continuation of the series on the hot topic of “Epigenetics in Neurodegenerative Diseases:”; our first Special Issue on this topic received interesting contributions and discussions (https://www.mdpi.com/journal/ijms/special_issues/Epigenetics_Neurodegenerative).
Recently, epigenetics—the study of the modification of gene expression that does not involve a change in the DNA sequence—has rapidly become established as a major topic in molecular biology and genetics. The two major components of epigenetics are DNA methylation and histone modifications. Additionally, microRNA (miRNAs), short molecules of RNA, can post-transcriptionally modulate their target mRNA, and they are key molecules for the normal control of gene expression. Epigenetic modifications have an important impact on human health and constitute an area of great interest for the study of several diseases, in particular multifactorial diseases. Neurodegenerative diseases, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, are complex diseases often with unknown pathogeneses. The interactions among different factors—genetics, inflammation, and environmental—play a role in their development and progression. For these reasons, the present Special Issue focuses on 1) DNA methylation; 2) histone modification; and 3) miRNA expressions in neurodegenerative diseases to better understand the molecular and biological mechanisms deregulated in these pathologies, which will lead to new roads of promising pharmacological and clinical therapies. Research articles (clinical studies, in vitro studies, and disease vs. control studies) as well as reviews are welcomed for this Special Issue.
Dr. Simone Agostini
Dr. Roberta Mancuso
Guest Editors
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Keywords
- epigenetics
- miRNAs
- DNA methylation
- histone modification
- sclerosis multiple
- Alzheimer’s disease
- Parkinson’s disease
- amyotrophic lateral sclerosis
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