ijms-logo

Journal Browser

Journal Browser

Special Issue "Mitochondrial Proteomics in Neuroscience and Neurodegenerative Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Viviana Greco
E-Mail
Guest Editor
Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, Italy
Interests: hydrogen sulfide; mass spectrometry; mitochondrial biochemistry; mitochondrial proteomics; neurodegenerative diseases; oxidative stress; PTMs; redox proteomics
Special Issues and Collections in MDPI journals
Dr. Luisa Pieroni
E-Mail Website
Guest Editor
Unità di Proteomica e Metabolomica, Fondazione S. Lucia IRCCS, 00179 Roma, Italy
Interests: proteomics; mitochondrial proteomics; mitochondria biology; neurodegenerative disease; metabolism; oxidative phosphorylation; biomarkers

Special Issue Information

Mitochondria play a key role as energy mediators and in the biosynthesis of eukaryotic cells, so they are recognized as the cell’s powerhouse. In addition to this function in cellular bioenergetics, mitochondria are involved in several other pathways such as the regulation of cell death processes, the modulation of ionic homeostasis, and the oxidation of carbohydrates and fatty acids. Therefore, it is not surprising that mitochondrial dysfunctions or alterations can have a serious impact both in defects of energy metabolism and in the multifactorial diseases in which they are directly involved.

The involvement of mitochondria in the pathogenic mechanisms of neurodegenerative disorders (for example amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and Down’s syndrome) has been well established. In recent years, many efforts have been made to understand these mechanisms, especially through the advances of the omics sciences.

From this perspective, mitochondria have become a “hotspot” for subcellular proteomics, with the aim of identifying clinical targets as candidate biomarkers in neurodegenerative diseases. 

The purpose of this Special Issue is to gather the latest information and highlight the state of the art in the progress of mitochondrial proteomics in order to highlight yet-unknown aspects, or to clarify the complex mechanisms, linked to mitochondrial dysfunction in neurodegenerative diseases.

Reviews, commentaries, and original research based on proteomics and mass spectrometry are welcome (for example, discovery, quantitative aspects, PTMs, and redox proteomics), independently or in combination with other, more classic biochemical, molecular, and cellular approaches.

Dr. Viviana Greco
Dr. Luisa Pieroni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Proteomics
  • Mass Spectrometry
  • Mitochondria
  • Mitochondria Function
  • Neurodegeneration
  • Metabolism
  • Neuronal activity
  • Neuronal plasticity
  • Mitochondrial protein function
  • Mitochondrial protein annotation
  • OXPHOS
  • Biomarkers
  • Aging
  • Drug Target
  • Drug Repurposing
  • Knowledge Base
  • Antibodies

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data
Int. J. Mol. Sci. 2021, 22(19), 10757; https://doi.org/10.3390/ijms221910757 - 05 Oct 2021
Viewed by 343
Abstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with extensive genetic and aetiological heterogeneity. While the underlying molecular mechanisms involved remain unclear, significant progress has been facilitated by recent advances in high-throughput transcriptomic, epigenomic and proteomic technologies. Here, we review recently published [...] Read more.
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with extensive genetic and aetiological heterogeneity. While the underlying molecular mechanisms involved remain unclear, significant progress has been facilitated by recent advances in high-throughput transcriptomic, epigenomic and proteomic technologies. Here, we review recently published ASD proteomic data and compare proteomic functional enrichment signatures with those of transcriptomic and epigenomic data. We identify canonical pathways that are consistently implicated in ASD molecular data and find an enrichment of pathways involved in mitochondrial metabolism and neurogenesis. We identify a subset of differentially expressed proteins that are supported by ASD transcriptomic and DNA methylation data. Furthermore, these differentially expressed proteins are enriched for disease phenotype pathways associated with ASD aetiology. These proteins converge on protein–protein interaction networks that regulate cell proliferation and differentiation, metabolism, and inflammation, which demonstrates a link between canonical pathways, biological processes and the ASD phenotype. This review highlights how proteomics can uncover potential molecular mechanisms to explain a link between mitochondrial dysfunction and neurodevelopmental pathology. Full article
Show Figures

Graphical abstract

Back to TopTop