Journal Browser

Journal Browser

Special Issue "Vitamin K and Vitamin K-Dependent Proteins in Homeostasis and Pathology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Dr. Dina Costa Simes
E-Mail Website
Guest Editor
Centro de Ciencias do Mar, Universidade do Algarve, Faro, Portugal
Interests: vitamin-K-dependent proteins (VKDPs); Gla-rich protein (GRP); pathological calcification; chronic inflammatory diseases; clinical, therapeutic, and biomolecular aspects of Vitamin K and VKDPs
Dr. Carla Viegas
E-Mail Website
Guest Editor
Centro de Ciencias do Mar, Universidade do Algarve, Faro, Portugal
Interests: Gla-rich protein (GRP); calcification-related chronic inflammatory diseases; cardiovascular calcification; pathological calcification–inflammation molecular crosstalk; VKDPs in inflammation; VKDPs biomarker and therapeutic potential; extracellular vesicles

Special Issue Information

Dear Colleagues,

Vitamin K (VK) is a multifunctional micronutrient with protective roles in many chronic inflammatory and age-related diseases such as cardiovascular diseases, diabetes, chronic kidney disease (CKD), arthritis, neurodegenerative disorders, cancer, mobility disability and frailty, and more recently linked to COVID-19. This wide range of biological effects has been attributed mainly to its function as a co-factor for the γ-carboxylation of extra-hepatic vitamin-K-dependent proteins (VKDPs), but novel γ-carboxylation-independent roles have been suggested. Molecularly, extra-hepatic VKDPs are involved in many biological functions such as bone homeostasis, ectopic calcification, cell differentiation and proliferation, inflammation, and signal transduction. Importantly, VK deficiency or impaired functionality of extra-hepatic VKDPs have been associated to pathological states, including poor COVID-19 prognosis, while VK diet supplementation is reported to have health-beneficial effects without toxic/adverse effects. This Special Issue is dedicated to highlighting recent advances in the field of VKDPs and vitamin K biology, providing novel molecular insights into their functional role in health and disease, and therapeutic and nutraceutical application. We invite authors to submit reviews or original research articles on any of the above topics.

Assist. Prof. Dr. Dina Costa Simes
Dr. Carla Viegas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • vitamin K1
  • menaquinones (MKn)
  • inflammation
  • pathological calcification
  • coagulation
  • vitamin-K-dependent proteins (VKDPs)
  • Gla-rich protein (GRP)
  • matrix-Gla protein (MGP)
  • osteocalcin (OC)
  • growth arrest-specific protein 6 (Gas6)
  • protein S
  • vitamin K nutrition

Published Papers

This special issue is now open for submission.
Back to TopTop