The Role of Toll-Like Receptor Signalling in Sterile Inflammation and Autoimmunity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 8528
Special Issue Editor
Interests: TLRs; NETs; autoimmune kidney diseases; ANCA vasculitis; CD4 T cells; microbiome in autoimmune kidney disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Toll-like receptors (TLRs) are key innate pattern recognition receptors (PRRs) which recognize pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPS). TLRs not only play a key role in host defense by recognizing PAMPs on microbes but also provide a strong link between infection, inflammation, and the development of autoimmunity. There is strong evidence that TLRs play a pivotal role in the promotion of inflammation without the presence of infection. TLRs play a non-redundant role in promoting tumor progression and recurrence in cancer, controlling immune responses that maintain gut homeostasis in inflammatory bowel disease, and promoting autoimmune kidney diseases such as Lupus Nephritis and anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). In the context of autoimmunity, self-components released through excessive cell death act as DAMPS, inappropriately activating TLRs. The stimulation of TLRs via their cognate ligands recruits down-stream adaptor molecules. Once these adaptor molecules have been activated, signaling cascades culminate in the activation of transcription factors, such nuclear factor-kB (NFkB) interferons, mitogen-activated protein (MAP) kinases, and response factors (IRFs). These immune response genes induce the production of inflammatory cytokines and inflammation. This Special Issue aims to provide an overview of TLR activation and signaling in the context of non-infectious sterile inflammation and autoimmunity.
Dr. Kim M. O'Sullivan
Guest Editor
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Keywords
- TLRs
- PRRs
- PAMPS
- signaling adaptor molecules
- inflammation
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