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Advances in Molecular Imaging of Breast and Gynecologic Cancers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2141

Special Issue Editor


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Guest Editor
Department of Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania
Interests: breast cancer; cancer imaging

Special Issue Information

Dear Colleagues,

Breast and gynecological cancers are among the most prevalent cancers to afflict women worldwide. An early diagnosis of the initial disease or recurrence and personalized treatment can significantly reduce physical morbidity and psychological distress in affected patients.

Molecular imaging (MI) allows functional and metabolic characterization of malignant lesions using advanced imaging acquisition techniques that detect targeted imaging agents with specific properties. MI provides insights into the biologic processes responsible for oncogenesis, assessing molecular and cellular pathways. Some of the current applications of MI in oncology are screening in high-risk populations, diagnosis of the early stage disease or recurrence, systemic staging, evaluation and optimization of neoadjuvant, and hormonal or molecular targeted therapy. MI modalities include PET and SPECT scans using different radiotracers, hybrid imaging such as PET/CT or SPECT/CT, functional MRI, optical imaging and targeted molecular ultrasound. Moreover, some breast-targeted techniques have been developed such as dedicated breast gamma imaging and breast-specific PET, the latter including positron emission mammography and dedicated breast PET.

This Special Issue aims to collect original research and review articles depicting new radiopharmaceuticals and their applications or potential nanotechnologies used in the management of breast or gynecological cancers.

Dr. Diana Gherman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • breast cancer
  • gynecological cancers
  • molecular imaging
  • functional imaging
  • radiotracer
  • advance nanotechnologies in oncological management

Published Papers (1 paper)

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Research

16 pages, 12982 KiB  
Article
A Comprehensive Analysis Revealing FBXW9 as a Potential Prognostic and Immunological Biomarker in Breast Cancer
by Shiyi Yu, Zhengyan Liang, Zhehao Fan, Binjie Cao, Ning Wang, Rui Wu and Haibo Sun
Int. J. Mol. Sci. 2023, 24(6), 5262; https://doi.org/10.3390/ijms24065262 - 9 Mar 2023
Cited by 2 | Viewed by 1809
Abstract
The WD40 repeat-containing F-box proteins (FBXWs) family belongs to three major classes of F-box proteins. Consistent with the function of other F-box proteins, FBXWs are E3 ubiquitin ligases to mediate protease-dependent protein degradation. However, the roles of several FBXWs remain elusive. In the [...] Read more.
The WD40 repeat-containing F-box proteins (FBXWs) family belongs to three major classes of F-box proteins. Consistent with the function of other F-box proteins, FBXWs are E3 ubiquitin ligases to mediate protease-dependent protein degradation. However, the roles of several FBXWs remain elusive. In the present study, via integrative analysis of transcriptome profiles from The Cancer Genome Atlas (TCGA) datasets, we found that FBXW9 was upregulated in the majority of cancer types, including breast cancer. FBXW expression was correlated with the prognosis of patients with various types of cancers, especially for FBXW4, 5, 9, and 10. Moreover, FBXWs were associated with infiltration of immune cells, and expression of FBXW9 was associated with poor prognosis of patients receiving anti-PD1 therapy. We predicted several substrates of FBXW9, and TP53 was the hub gene in the list. Downregulation of FBXW9 increased the expression of p21, a target of TP53, in breast cancer cells. FBXW9 was also strongly correlated with cancer cell stemness, and genes correlated with FBXW9 were associated with several MYC activities according to gene enrichment analysis in breast cancer. Cell-based assays showed that silencing of FBXW9 inhibited cell proliferation and cell cycle progression in breast cancer cells. Our study highlights the potential role of FBXW9 as a biomarker and promising target for patients with breast cancer. Full article
(This article belongs to the Special Issue Advances in Molecular Imaging of Breast and Gynecologic Cancers)
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