Mitochondrial Membrane Complexes in Intracellular Communication and Diseases
A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Biological Membrane Composition and Structures".
Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 301
Special Issue Editors
Interests: machinery of the protein import into mitochondria of Amoebozoa - the structure, function and evolution; mitochondria and ccfDNA in Parkinson diseases
Interests: mitochondria-mediated cytoprotection and cytotoxicity; anhydrobiosis as an anti-aging strategy; the role of VDAC in adaptation to habitat conditions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to a Special Issue titled “Mitochondrial membrane complexes in intracellular communication and diseases”.
In eukaryotic cells, mitochondria are crucial organelles for the transformation of energy into ATP. One development of the endosymbiotic theory is the necessity of the delivery of the mitochondrial proteins, so called preproteins, which are mostly synthesised in the cytosol. The preproteins are imported into the various mitochondrial sub-compartments, where their proper delivery is based on the mitochondrial membrane proteins forming complexes called translocases in the outer and inner mitochondrial membranes. They assure proper recognition and translocation into the membrane, into the intermembrane space, or into the matrix. The mitochondrial membrane complexes are also engaged in a specialized mitochondrial quality control system as an answer to the genetic changes and proteinaceous content causing abnormal changes of the mitochondrial structure and function. Mitochondria make functionally relevant contacts with most organelles in the cell. Together with endoplasmic reticulum (ER) they form the mitochondria-associated membrane complex (MAM), which constitutes a key signalling hub to regulate several fundamental intracellular processes and integrates organelle communication and function with cellular metabolism and homeostasis. On the other hand, inside mitochondria there is the MICOS complex which integrates two mitochondrial membranes and participates in the generation of mitochondrial architecture, lipid metabolism and the previously mentioned preprotein import into mitochondria. Finally, apoptosis, fusion and fission processes rely on the mitochondrial membrane complexes working as specialized receptors which are regulated by a wide variety of molecules.
The goal of the proposed Special Issue, Mitochondrial membrane proteins in intracellular communication and diseases, is to collect all available mechanisms of intervention into mitochondrial functioning, so as to prevent or repair unwanted changes in mitochondrial structure and function. The Issue is also focused on the mitochondrial membrane complexes and their abnormalities in the light of human diseases, including neurodegenerative diseases like Parkinson’s and Alzheimer’s as well as cancer. In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.
Dr. Małgorzata Wojtkowska
Prof. Dr. Hanna Kmita
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- respiratory chain
- protein channels
- protein import
- membrane complexes
- mitochondria contact sites
- mitochondria dynamics
- signalling cascades and molecules
- cell death
- human diseases
- Parkinson’s
- Alzheimer’s
- cancer
