From Molecular to Systems Biology through Data Integration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 600
Special Issue Editor
2. Department of Laboratory Medicine, ASST "Grande Ospedale Metropolitano" Niguarda, 20162 Milan, Italy
Interests: computational modeling of biological networks; data science; omics; personalized drug responses; artificial intelligence; systems biology; ethics of AI
Special Issue Information
Dear Colleagues,
Omics-based approaches used to identify disease mechanisms and drug responses have produced massive amounts of data, now accessible through indexed journals, reviews, and public and navigable repositories, thanks to technological advancements.
In this context, systems biology has developed into a discipline that uses complex computational and mathematical models to investigate the interactions between various biological entities (proteins, metabolites, genes, cells, organs, tissues, and the environment). In this scenario, we can reveal phenotype as a reflection of the several simultaneous molecular interactions occurring at any one time from various levels, combined holistically.
Current research is limited to studying the molecules themselves while ignoring the effects of their interactions with the environment. Therefore, systems biology contrasts the standard concept of the reductionist approach, using the study of dysregulation in isolated molecular components as a starting point to identify distinct changes in the patterns of intermolecular relationships.
The time is ripe, and thus we must reap the benefits of integrating molecular data with the repositories present in the literature (es interactome, pathways or network analysis) and in clinical practice data. This Special Issue is an exciting opportunity to shed light on the importance of data integration in systems biology to better support the discipline of precision medicine. Original papers, review articles, and protocols from experts in the field are welcome.
Dr. Elvira Inglese
Guest Editor
Manuscript Submission Information
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Keywords
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bioinformatic methods in systems biology
- data-driven and dynamic modeling approaches
- network analysis
- data integration methods
- digital twin
- omics-based research
- interactome analysis
- network pharmacology
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