Epigenetic Drugs for Soft Tissue Sarcomas
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Role of Xenobiotics".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 3207
Special Issue Editor
Interests: cancer epigenetics; rhabdomyosarcoma; EZH2; SCLC; MYC; small molecules; nanoparticles; cytotoxicity; cell proliferation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Soft tissue sarcomas are a group of rare malignant tumors that develop from human soft tissues such as nerve, muscle, blood vessels, and fat. They originate from mesenchymal progenitor stem cells and are associated with a poor prognosis. The most common therapies include mainly surgical, chemotherapeutic, and radiotherapeutic approaches. However, the response rates of sarcomas to chemotherapy are rather low, and sarcoma cells may have intrinsic or acquired resistance after treatment with chemotherapeutic drugs, leading to the development of multidrug resistance (MDR). The overall 5-year survival rate of soft tissue sarcoma is 50%, and no particular improvements have been noted in the last few decades. Epigenetic dysregulation is very often observed in the pathogenesis of soft tissue sarcomas. More recently, epigenetic regulators, such as DNA methyltransferases, histone deacetylases, and histone-modifying enzyme Enhancer of Zeste Homolog 2 have gained attention as potential therapeutic targets. The recent development of numerous small-molecule inhibitors of these epigenetic regulators is allowing to identify novel potential therapeutic approaches in the treatment of different malignancies. However, epigenetic-targeted therapy in sarcomas still needs to be expanded and studied in order to understand the mechanisms to improve the clinical outcome. This Special Issue aims to gather reviews and original articles related to cutting-edge clinical advances in epigenetic therapies for soft tissue sarcomas, focusing also on treatments which combine epigenetic therapeutics to the current pharmacological therapies in order to improve clinical response.
Dr. Luigi M. Bagella
Guest Editor
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Keywords
- sarcomas
- epigenetics
- drugs
- rhabdomyosarcoma
- EZH2
- cytotoxicity
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