Heterogeneity and Precision Oncology in Circulating Tumor Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 5284
Special Issue Editors
2. Institute for Glycomics, Griffith University, Gold Coast, QLD 4222, Australia
Interests: molecular pathology; cancer; anticancer drugs; cancer marker; drug delivery; cancer pathogenesis
Interests: diagnosis of cancer; molecular pathology of cancer; treatment of cancers; endocrine cancer; gastrointestinal cancer; head and neck tumors
Special Issue Information
Dear Colleagues,
Circulating tumor cells (CTCs) are a rare subpopulation of cells found in the blood of patients with cancer. CTCs present in the blood have the potential to be used as a liquid biopsy for the early diagnosis, prognosis, and therapy response related to various cancers (e.g., breast, colon, gastric, lung, prostate, and hematological malignancies), in comparison to more conventional forms of tumor tissue biopsies. It is a treatment that is less invasive, more precise, and can be processed rapidly by collecting peripheral blood from the patients. As they share common genetic and/or epigenetic alterations similar to primary/secondary tumors, the real-time sampling of CTCs could provide us with a critical insight into the tumor’s molecular structure (i.e., the heterogeneity of cancer) without resorting to the use of an invasive tissue biopsy, which can be useful in therapy selection and response monitoring in cancer patients. The heterogeneous nature of cancer is associated with inefficient clinical outcomes; therefore, the characterization of CTCs followed by their identification in clinical settings has the potential for use as an effective prognostic and therapeutic biomarker for selecting personalized precision-treatment options, resulting in the improved management of patients with cancer.
Dr. Farhadul Islam
Prof. Dr. Alfred King-Yin Lam
Guest Editors
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Keywords
- cancer progression
- cancer pathogenesis
- prognostic marker
- cancer heterogeneity
- precision oncology
- circulating tumor cells
- cancer screening
- therapy response
- survival
- CTC isolation
- CTC enrichment
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