Molecular Research on the Pathogenesis of Uremia and Effects of Hemodialysis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 3547
Special Issue Editor
Interests: chronic kidney disease; hemodialysis; uremia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Various molecules are involved in the detrimental processes observed during kidney function, leading to the development of uremia, which results in the kidneys failing to excrete waste and/or excessive water. In the milieu of uremia, the accumulation of various exogenous and endogenous toxins causes systemic manifestations, including cardiovascular, immunological, hematologic, metabolic, neurological, musculoskeletal, gastrointestinal, and dermatological problems.
Hemodialysis (HD) has been a practical treatment modality for kidney failure, regardless of acute kidney injury or end-stage kidney disease. During HD, a substantial amount of low-molecular-weight uremic toxins are cleared, whereas medium and large molecules are removed less efficiently. Meanwhile, the exposure of immune cells to extracorporeal circulation, including tubing and artificial kidneys, induces the expression of pro-inflammatory cytokines and worsens oxidative stress. The backfiltration of hazardous substances from dialysate to blood is also a unique phenomenon observed during HD therapy.
Thus, to elaborate on the molecular mechanisms involved in the pathogenesis of uremia is essential for the effective prevention of uremia. Additionally, to clarify the clearance and induction of biologically active molecules related to HD, therapy is necessary in order to achieve better care for HD patients and is worthy of more effort.
The Special Issue, titled “Molecular Research on the Pathogenesis of Uremia and Effects of Hemodialysis”, aims to provide a platform for the collection of the latest original and review articles covering molecular biological studies related to the pathogenesis of uremia and the effects of hemodialysis, serving as inspiring references for further research.
Best regards,
Dr. Shihping Hsu
Guest Editor
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Keywords
- biocompatibility
- hemodialysis
- oxidative stress
- uremic toxins
- pro-inflammatory cytokines
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