Role of Water in Protein Folding and Activity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 5495
Special Issue Editors
Interests: bioinformatics-proteomics; protein structure prediction; amyloidosis; systems biology; construction of proteome; simulation in medicine
Special Issue Information
Dear Colleagues,
The role of water in determining the biological activity of proteins is of primary importance. Life as we know it on our planet is designed to be active in the aquatic environment. This condition is so obvious that it does not get enough attention. Models of biomolecular systems including water mainly use representations of the set of individual water molecules and their interactions at the atomic level. The model of the water environment conditioning biological activity deserves much more attention. Therefore, this Special Issue is addressed to Authors studying the properties of the water environment to encourage them to present their results.
The phenomenon of the construction of spherical micelles formed by bipolar particles is an example of the effects of the presence of an external field. The formation of micelles is an expression of the influence of the water environment on the processes taking place in it.
The interaction of the water environment with the hydrophobic surface is of particular importance. High hydrophobicity, exposed locally on the surface of proteins, is important for the communication between molecules. The search for a mechanism accompanying this phenomenon is of critical importance for the recognition of processes described as specific, because the flow of communication through water determines the course of these and many other processes.
Dr. Irena Roterman-Konieczna
Dr. Jan Zielkiewicz
Dr. Andrzej Sokalski
Dr. Katarzyna Stapor
Guest Editors
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Keywords
- amyloids
- amyloid transformation
- downhill folding
- edge ß-strand
- information entropy
- external force field
- hydrophobic core
- hydrophobicity
- negative feedback loop
- protein folding
- water environment
- active participation of water in folding process
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