Dear Colleagues,

Sarcopenia, the progressive age-related loss of skeletal muscle mass and strength/function during aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. Several processes and mechanisms have been indicated as contributors to age-related muscle tissue disruption. Factors spanning muscle-specific processes (e.g., mitochondrial dysfunction in skeletal myocytes) to systemic changes (e.g., inflammation and amino acid dysmetabolism) have been pinpointed as possible contributors to the pathophysiology of sarcopenia. The search for biomarkers that may allow early identification and tracking of the condition over time is very active. This Special Issue is intended to bring together basic researchers and clinicians working in sarcopenia in human and animal models to gain additional insights into the molecular mechanisms involved in the pathophysiology of sarcopenia and unveil novel biomarkers for the condition. With these premises, the ultimate aims of this Special Issue are to shed light on biological targets for interventions against sarcopenia and to identify novel biomarkers for the condition.

Dr. Anna Picca
Dr. Riccardo Calvani
Guest Editors

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• muscle aging
• functional impairment and frailty
• mitochondrial dysfunction
• cellular quality control
• redox biology
• inflammation
• biomarkers
• omics
• gut microbiota
• geroscience