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Article

Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice

R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Korea
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Academic Editor: Anuska V. Andjelkovic
Int. J. Mol. Sci. 2021, 22(18), 10023; https://doi.org/10.3390/ijms221810023
Received: 11 August 2021 / Revised: 6 September 2021 / Accepted: 13 September 2021 / Published: 16 September 2021
Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person’s quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can improve muscle mass and muscle strength and affect physical performance. Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The present research shows that L. plantarum HY7715 increases physical performance and skeletal muscle mass in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging. View Full-Text
Keywords: aging; probiotics; Lactobacillus plantarum HY7715; sarcopenia; skeletal muscle aging; probiotics; Lactobacillus plantarum HY7715; sarcopenia; skeletal muscle
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MDPI and ACS Style

Lee, K.; Kim, J.; Park, S.-D.; Shim, J.-J.; Lee, J.-L. Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice. Int. J. Mol. Sci. 2021, 22, 10023. https://doi.org/10.3390/ijms221810023

AMA Style

Lee K, Kim J, Park S-D, Shim J-J, Lee J-L. Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice. International Journal of Molecular Sciences. 2021; 22(18):10023. https://doi.org/10.3390/ijms221810023

Chicago/Turabian Style

Lee, Kippeum, Jisoo Kim, Soo-Dong Park, Jae-Jung Shim, and Jung-Lyoul Lee. 2021. "Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice" International Journal of Molecular Sciences 22, no. 18: 10023. https://doi.org/10.3390/ijms221810023

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