Molecular Mechanisms of Fibrosis in Cardiomyopathy and Heart Failure
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 8
Special Issue Editor
Interests: epithelial–mesenchymal transition (EMT); fibrosis; cancer; heart failure; translational medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiomyopathy and heart failure remain leading causes of morbidity and mortality worldwide, with cardiac fibrosis representing a central mechanism driving disease progression. Fibrosis, largely mediated by epithelial–mesenchymal transition (EMT), leads to maladaptive myocardial remodeling, impaired contractility, and ultimately severe heart failure. Increasing evidence is highlighting the role of non-coding RNAs, especially microRNAs (miRNAs), as key regulators of EMT and as potential biomarkers of disease stage and treatment response. However, despite rapid advances, the molecular mechanisms underlying fibrosis in human cardiomyopathy remain incompletely understood, and effective antifibrotic therapies are still lacking.
This Special Issue will showcase cutting-edge research and comprehensive reviews addressing the molecular, cellular, and translational aspects of fibrosis in cardiomyopathy and heart failure. We particularly welcome studies focusing on EMT pathways, microRNA profiling, extracellular matrix remodeling, and biomechanical alterations in the failing heart. Submissions exploring innovative diagnostic approaches, the bioinformatic integration of omics data, preclinical therapeutic strategies—including drug repurposing—and clinical perspectives on fibrosis monitoring are especially encouraged.
By providing a platform for interdisciplinary dialog across molecular biology, cardiology, and translational medicine, this Special Issue will foster new insights into fibrosis mechanisms and their clinical implications. Our ultimate goal is to support the development of novel biomarkers and targeted therapies that may improve risk stratification, personalized treatment, and patient outcomes in advanced heart failure.
We look forward to receiving your contributions.
Dr. Dorota Ciołczyk-Wierzbicka
Guest Editor
Manuscript Submission Information
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Keywords
- epithelial–mesenchymal transition (EMT)
- microRNA (miRNA)
- biomarkers cardiac fibrosis
- cardiomyopathy heart failure
- molecular mechanisms
- translational cardiology
- personalized medicine
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