Effects of Malnutrition of Immune Response

A special issue of Immuno (ISSN 2673-5601).

Deadline for manuscript submissions: 30 December 2024 | Viewed by 1792

Special Issue Editor


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Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, The Czech Advanced Technology and Research Institute (Catrin), Palacky University, Hněvotínská 1333/5, 779 00 Olomouc, Czech Republic
Interests: inflammation; immunology; flow cytometry; metabolism; cell culture; immunology of infectious diseases; autoimmunity; pharmacology; gene expression; genetics; RNA
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Special Issue Information

Dear Colleagues,

According to the World Health Organization, “malnutrition refers to deficiencies, excesses or imbalances in a person’s intake of energy and/or nutrients. The term malnutrition covers 2 broad groups of conditions. One is ‘undernutrition’—which includes stunting (low height for age), wasting (low weight for height), underweight (low weight for age) and micronutrient deficiencies or insufficiencies. The other is overweight, obesity and diet-related noncommunicable diseases. Around 1.9 billion adults worldwide are overweight, while 462 million are underweight.” Therefore, malnutrition represents a major medical problem that affects people of all ages and predisposes them to several diseases, affecting immune response. The scope of this Special Issue is to offer an updated view on the subject from different perspectives, including in vivo research on humans and animals, as well as in vitro research. 

Prof. Dr. Juan Bautista De Sanctis
Guest Editor

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Keywords

  • malnutrition
  • immune response
  • oligoelements
  • vitamins
  • innate immune response
  • adaptive immune response
  • children
  • aging
  • immune aging

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Published Papers (1 paper)

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Review

17 pages, 3060 KiB  
Review
Protective Mechanisms of Carica papaya Leaf Extract and Its Bioactive Compounds Against Dengue: Insights and Prospects
by Tanvir Zaman Shoyshob, Irin Amin Heya, Nusrat Afrin, Mansura Akter Enni, Israt Jahan Asha, Akhi Moni, Md. Abdul Hannan and Md. Jamal Uddin
Immuno 2024, 4(4), 629-645; https://doi.org/10.3390/immuno4040037 - 12 Dec 2024
Viewed by 780
Abstract
Dengue fever is currently a major global issue, especially in tropical and subtropical countries. The absence of specific antiviral medications supports alternative dengue treatment strategies. South Asian countries have been using Carica papaya leaves as a traditional remedy for dengue for many years. [...] Read more.
Dengue fever is currently a major global issue, especially in tropical and subtropical countries. The absence of specific antiviral medications supports alternative dengue treatment strategies. South Asian countries have been using Carica papaya leaves as a traditional remedy for dengue for many years. Carica papaya possesses several biological features, including anti-inflammatory, antiviral, cancer-fighting, anti-diabetic, and antioxidant qualities. Additionally, numerous studies have demonstrated that bioactive compounds found in papaya leaf extracts, including carpaine, dehydrocarpaine I and II, chymopapain, and papain, significantly influence platelet counts, while phenolic compounds, such as chlorogenic acid, kaemferol, protocatechuic acid, quercetin, and 5,7-dimethoxycoumarin significantly inhibit viral replication in dengue patients, with negligible side effects. Carica papaya may be considered a viable pharmacological candidate with several targets for treating dengue. It has been shown to prevent infections, reduce oxidative stress, control cytokine storms and the immune system, lessen thrombocytopenia, and increase the body’s protein and hemoglobin levels. This literature review highlights the pathophysiological mechanism of dengue, as well as the pharmacological action of Carica papaya, both of which combat this debilitating disease. Despite these findings, additional investigation, including clinical studies, is necessary to confirm the effectiveness and safety of papaya-based treatments. It is necessary to address issues like standardizing papaya extracts, figuring out the best dosages, and assessing any drug interactions. Full article
(This article belongs to the Special Issue Effects of Malnutrition of Immune Response)
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