The Promise of Precision Oncology in Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 23481
Special Issue Editor
Special Issue Information
Dear Colleagues,
Breast cancer remains a leading cause of death among women worldwide. While we acknowledge some of the best examples of targeted treatments exist for this cancer type (i.e., hormone therapy in ER-positive and anti-HER2 treatment in HER2 amplified tumors), we are still far from implementing truly personalized patient management.
Extensive molecular characterization has revealed inter- and intra-tumor heterogeneity as hallmarks of the disease. Similarly, a functionally relevant heterogeneity has been observed in the tumor microenvironment. Such diversity implies the necessity for innovative and tailored therapeutic interventions; however, our understanding of the mechanisms determining treatment response is still unsatisfactory. Technological development has enabled genome-wide measurements, multi-omic approaches and single-cell resolution analysis, providing an unprecedented ability to capture the complexity of cancer as a system. In this context, computational biology has a key and expanding role for the effective exploitation of the increasing amount of data generated.
This Special Issue “The Promise of Precision Oncology in Breast Cancer” of the International Journal of Molecular Sciences will publish a collection of the latest high-quality research papers, contributing to precision oncology in breast cancer patients.
Dr. Maurizio Callari
Guest Editor
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Keywords
- Breast cancer
- precision oncology
- biomarkers
- omics
- mechanism of resistance
- tumor microenvironment
- pharmacogenomics
- pharmacoproteomics
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